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Chemistry and Biology of Peptides

Gordon Research Conference

Exploring Peptides as Natural and Unnatural Scaffolds for Discovery

February 11 - 16, 2024

Chairs

and

Vice Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The Chemistry and Biology of Peptides GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 GRC Chemistry and Biology of Peptides conference will feature the breadth of peptide science. Sessions will focus on topics ranging from organic synthesis of natural and non-natural peptide scaffolds, the utilization of peptides as chemical biology tools, and translating those peptide discoveries to the clinic, but will also highlight new tools and technologies enabling peptide discovery efforts.

Related Meeting

This GRC will be held in conjunction with the "Chemistry and Biology of Peptides" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Expanding Boundaries for Peptide Applications Discussion Leaders: and
7:40 pm - 8:20 pm	"Probing Informational Properties of Polypeptides with Non-Canonical Modifications"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"High-Throughput Evolution of Biosynthetic Assembly Lines"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Innovations in Peptide Chemistry Discussion Leaders: and
9:00 am - 9:20 am	"Recent Advances in Greener Peptide Synthesis"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Talk Selected from GRS
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Catalytic Amyloids"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:05 am	"Understanding the Oral Bioavailability of Macrocyclic Peptides by Masking the Backbone H-Bond Acceptors and Donors"
11:05 am - 11:10 am	Discussion
11:10 am - 11:25 am	Talk Selected from GRS
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Natural Product-Inspired Synthesis of Cyclic Antimicrobial Peptides"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Pyridoxal Radical Biocatalysis for the Stereoselective Synthesis of Non-Canonical Amino Acids"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Peptide Therapeutics: From Bench to Clinic Discussion Leaders: and
7:30 pm - 7:50 pm	"Technologies for the Discovery of Helically Constrained Peptide Therapeutics"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"From Metabolic Diseases to Cancer "Peptides as a Force for Drug Discovery""
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Anti-Tumor Activity of ST101, A Peptide Antagonist of the Transcription Factor CCAAT/Enhancer Binding Protein ß"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Engineering Passive Permeability into Macrocyclic Peptides Targeting KRAS"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Peptidomimetics and Alterative Scaffolds Discussion Leaders: and
9:00 am - 9:20 am	"(Not) Sorry to Burst your Bubble: Peptoids as Membrane-Active Antivirals"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"3D-Printed Scaffolds with Tunable Growth Factor-Mimetic Peptide Presentation"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Metabolically Stabilized Triazolo-Peptidomimetics for Tumor Targeting"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Applications of Amidine Isosteres to Study Peptide Folding and Function"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Irregular Secondary Structures as Minimal Preorganizing Units in Peptides"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Peptides in Motion to Create Biomimetic and Bioactive Soft Matter"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tools and Technologies Enabling Peptide Discovery Discussion Leaders: and
7:30 pm - 7:50 pm	"Empower Accurate Peptide and Protein Insights with Game-Changing Chemical Probes and Advanced MALDI-MS Strategies"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Ion Mobility Separation of Modified Peptides"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"A Small Molecule with Big Impact: The Story of a Multifunctional Catch-and-Release Linker for Simple to Complex Peptides"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Beyond Purified Proteins: Cyclic Peptide Discovery in a More Native Environment"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Peptides and Delivery Discussion Leaders: and
9:00 am - 9:20 am	"Oral Biologic Drug Delivery Using Robotic Microneedle Pills"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"FOX-Three Intracellular Delivery Platform: Peptidic Molecular Guidance Systems for Cell Specific Delivery of Biologics"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Sequence Programmable Order-Disorder Transitions in Peptide Self-Assembly"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Proteomimetic Polymers for Expanding the Druggable Proteome"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Permeation of Peptides Across the Outer Membrane Layer of Bacteria"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Harnessing the Potential of Structured Oligomers for Biomolecule and siRNA Intracellular Delivery"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Naturally and Unnaturally Modified Peptides Discussion Leaders: and
7:30 pm - 7:50 pm	"Unnatural Peptides for Selective Recognition of Hsp70s"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Molecular Craftsmanship: Techniques and Advancements in Glycopeptide Synthesis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Traceless C–H Functionalization of Peptides"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Photochemically-Enabled, Post-Translational Production of Therapeutic C-Terminal Amides"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Peptides and Chemical Biology Discussion Leaders: and
9:00 am - 9:20 am	"Selective Chemistry on Proteins - His Tag Acylations"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Optogenetic Sensors and Chemogenetic Tools for Studying Brain Signaling"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Synthetic Natural Product Inspired Cyclic Peptides for Discovery of Bioactive Natural Products and Biocatalysts"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Membrane-Active Peptides Escape Drug Resistance and Do Not Change Lipid Composition in Cancer Cells"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Leveraging Peptide Chemistry and Antibody Recognition to Target Cell Surface Receptors"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Unraveling the Signaling of Endogenous Cell-Cell Signaling Peptides"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Navigating Funding Opportunities at NIGMS"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Expanding Beyond Metathesis Discussion Leaders: and
7:30 pm - 8:15 pm	"New Technologies for the Synthesis and Semi-Synthesis of Modified Proteins"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	Alexander M. Cruickshank Lecture: "Chemical Strategies to Intercept and Alter Bacterial Communication Pathways"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Chemistry and Biology of Peptides (GRS)

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