Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Tetrapyrroles: Chemistry and Catalysis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Coordination and Electronic Structures of Short-Lived Intermediate in Heme-Containing NO Reductases"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Unraveling the Chemistry of Reversible Heme Binding"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Unusual Heme Binding and Its Functional Significance in Heme-Regulated Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heme Synthesis and Pathophysiology
9:00 am - 9:25 am
"ALA Synthases and Their Substrates: The Heme Gatekeepers"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"RNAi Therapeutics for Acute Hepatic Porphyrias"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Adaptive Responses to Heme-Induced Neuronal Stress: SEeing Is Believing"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"FAM210B Is an Erythropoietin Target and Regulates Erythroid Heme Synthesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulatory Pathways in Chlorophyll and Energy Production
7:30 pm - 7:55 pm
"Multiple Posttranslational Control Mechanisms on Glutamyl-tRNA Reductase"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Regulation of Chlorophyll Metabolism by Mg-Dechelatase"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Redox and Light Control of Tetrapyrrole Synthesis in an Anoxygenic Phototroph"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Bridging the Gap: How Magnesium Chelatase Harnesses ATP Hydrolysis to Power Metal Ion Insertion"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Heme Trafficking and Imaging
9:00 am - 9:25 am
"Heme Trafficking and Modification in Cytochrome c Biogenesis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Heme Gazing: Elucidating Heme Trafficking and Signaling with Fluorescent Heme Sensors and Affinity Reagents"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Quantifying Heme Levels in Malarial Parasites Through Imaging"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Label-Free Transient Absorption Imaging of Heme Storage, Transport, and Modifications"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Heme Transport and Recycling "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Heme Regulatory Motifs of Heme Oxygenase-2 Function to Transfer Heme to the Catalytic Site for Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"GAPDH Regulates Allocation of Bioavailable Heme in Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Linear Tetrapyrroles and Photoreceptors
7:30 pm - 7:55 pm
"Life on the (Far)-Red-Edge of Darkness: How Terretrial Cyanobacteria Sense and Respond to Far-Red Light"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Functional Diversification of Two Bilin Reductases for Photoperception and Photosynthesis in a Unique Cyanobacterium Acaryochloris marina "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Type IV Chromatic Acclimation in Marine Synechococcus "
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Spectroscopic Evidence for Electronic Control of Heme Hydroxylation by IsdG"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biosynthesis, Trafficking and Homeostasis of B12 and Corrinoids
9:00 am - 9:25 am
"The Partitioning of Metals in Tetrapyrrole Biosynthesis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cofactor Specificity in Corrinoid-Dependent Bacteria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"B12 Trafficking and Its Modulation by Itaconate"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Elucidating the Mechanistic Underpinnings of Cobalamin in Microbial Cell Growth, Gene Regulation, and Enzyme Activity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cobalamins for Biomimetic Studies and Medicinal Applications"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structure of Human Aminolevulinate Synthase Reveals a Strong Evolutionary Divergence in C-Terminal Regulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Investigating the Molecular Basis of Vitamin B12 Uptake in Algae"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Tetrapyrroles: Degradation and Signaling
7:30 pm - 7:55 pm
"Discovery of NO-Responsive Hemoproteins and Their Roles in Biofilm Regulation"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic Tools Engineered from Bacterial Phytochromes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Heme, Bile Bigments and Beyond: Bilirubin Oxidation Products and Liver Function Under Stress Conditions"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Extracellular Heme Sensor HasAp Is Central to Heme Metabolism and Virulence"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tetrapyrroles at the Host-Pathogen Interface
9:00 am - 9:25 am
"Heme-Induced Cell Signaling in Aedes aegypti "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Porphyrin Trafficking and Metabolism in Trypanosomatid Protozoan Parasites"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Impact of Heme in the Host-Pathogen Relationship"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Heme Utilization by Blood-Stage Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Neutron Structure of a Peroxidase-Substrate Complex Reveals Neutral Arginine in Proton Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Investigation of Determinants Mediating ALAS Cofactor Binding"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Toxoplasma gondii , an Obligate Intracellular Protozoan Pathogen, Relies on Its own Heme Biosynthesis for Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Tetrapyrrole Homeostasis: From Microbes to Man
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
"Macrocyclic Tetrapyrroles: The 72 Steps to the Pigments of Life"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:35 pm
Introduction by Discussion Leader
8:35 pm - 9:15 pm
"Biological Lessons from Patients with Inherited Disorders of Cobalamin Metabolism"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure