Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Structural Techniques for the Study of Tetrapyrroles
This session is devoted to the application of new structural approaches (such as serial femtosecond X-ray crystallography) to the study of tetrpyrrole systems.
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Bacterial Heme Proteins Involved in Sensing and Regulation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Time-Resolved Serial Crystallography: Methods and Applications at Synchrotrons and XFELs"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Heme Controls the Structural Rearrangement of its Sensor Protein Mediating the Survival of Hemolytic Bacterial"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Trafficking, Signalling and Regulation by Heme
This session will focus on how tetrapyrroles, principally heme, are trafficked, can signal and play regulatory roles in eukaryotic cells.
9:00 am - 9:25 am
"Globin Coupled Sensors in Bacterial O2 and NO Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Selective Depletion of Endogenous CO In Vitro and In Vivo by Hemoprotein Biomimetic Model Complexes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"GAPDH-Dependent Heme Trafficking and its Regulation"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Fluorescence Lifetime Imaging Microscopy Reveals the Mechanisms Controlling Heme Supply and Deman"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Heme and Hemoglobin Alter Biofilm Formation by Mycobacterium smegmatis "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Functional Adaption of Human HRG1 as an Intestinal Heme Transporter"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biogenesis and Functions of Bilins
Bilins are linear tetrapyrroles derived from the oxygenolytic turnover of heme found in most kingdoms of life. This session will focus on their biogenesis and diverse functions from light sensing, signaling to ROS mitigation.
7:30 pm - 7:55 pm
"Phycocyanobilin Biosynthesis in Eukaryotic Algae"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Phycobiliproteins of Cryptophyte Microalgae"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Anaerobic Heme Degradation in Enteric Pathogens"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"TSPO Proteins Convert Protoporphyrin IX to Bilindigin, a Newly Discovered Tetrapyrrole"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tetrapyrroles in Human Health and Disease
The session will explore the structure and reactivity of different tetrapyrrole systems, with an emphasis on mechanism.
9:00 am - 9:25 am
"Investigation of Hepatocyte Heme Homeostasis In ALAS-Deficient Mice: The Dogma Revisited"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Aminolevulinic Acid Synthase 2 (ALAS2) Inhibition to Treat Erythroporphyrias"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Heme and Hemoglobin Down-Regulate Neuroinflammation and Glial Clearance of Amyloid Beta"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"The Role of Abcb10 in Mitochondrial Homeostasis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"From Microbial Sensor to Therapeutic Scavenger: Development of a Novel Treatment for Carbon Monoxide Poisoning Inspired by a Hemoprotein Biosensor"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Heme-Sequestering Plant Peptide Promotes Iron Uptake in Symbiotic Bacteria-Significance and Potential Clinical Applications"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Chemical Proteomic Map of Heme-Protein Interactions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biology of Tetrapyrroles: Catalysis, Mechanism and Regulation
A session on the newest ideas of the role of heme proteins and heme metabolites in sensing and regulation.
7:30 pm - 7:55 pm
"Modeling Mechanistic Subtleties of Nitric Oxide Synthase: A Missing Link in Understanding Human Pathogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"The Interaction of SARS-CoV-2 Spike Glycoprotein with Tetrapyrroles"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Developing a Structural Model for the DNA Complex of Aerobic CO-Sensing Transcription Factor, PxRcoM-1"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Product Distributions for Non-canonical Heme Oxygenases Depend Upon Enzyme-induced Heme Substrate Ruffling"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
B12: Biosynthesis, Transport, Pharmacology and Mechanistic Enzymology
This session will cover the recent discoveries of how B12 is assembled and then its involvement in important biomedical and biochemical processes. This includes its collaboration with radical SAM in a wide class of enzymatic reactions, its ability to transport RNA into cells in some cases by RNA-dependent processes, and its pharmacology.
9:00 am - 9:25 am
"Vitamin B12 Derivatives and Conjugates for Biomedical Applications"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"B12 Metabolism and the Epigenome in Chlamydomonas "
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"X-ray Spectroscopy and Theoretical Investigations of the B12 Cofactor"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Acquisition of Cobalt for Vitamin B12 "
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Inhibition of B12 Dependent Enzymes and Chaperons by Vitamin B12-Antimetabolites"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Eukaryotic Homologs of CobT Activate Lower Ligands of Vitamin B12 and other Cobamides"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Regulation and Biosynthesis of Chlorophyll Pigments
This session is aimed at highlighting new details about how the primary chlorophyll pigments of photosynthesis are synthesized and understanding the regulation of photosynthetic gene expression.
7:30 pm - 7:55 pm
"Regulation and Biosynthesis of Red-Shifted Chlorophylls: Current Status"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"An Interaction Between Photosynthetic Electron Transport, Chlororespiration and Chlorophyll Biosynthesis in Chlamydomonas "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Cyclase Step in Chlorophyll Biosynthesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbial Tetrapyrrole Metabolism
This session will focus on microbial mechanisms of tetrapyrrole synthesis, uptake, utilisation, and degradation.
9:00 am - 9:25 am
"New Insights into Heme Degradation by IsdG-Type Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Biochemistry of Enzymes Involved in the Coproporphyrin-Dependent Heme Biosynthesis Pathway of Gram-Positive Bacteria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Taming the Heme: The Chemistry of Microbial Hemoglobins"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Structural and Functional Basis of Bacterial Heme Export Facilitated by CydDC"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Functional Characterization of the Radical SAM Enzyme NirJ Involved in Heme d1 Biosynthesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"PufQ, a Ferrochelatase Binding Protein that Regulates Bacteriochlorophyll Biosynthesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Tetrapyrrole Regulation and Homeostasis
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
"Biliverdin: A Green Light for Heme Utilization and Virulence in Pseudomonas aeruginosa "
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Heme: A Pigment on the Bacterial Palette and the Vegan Palate"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure