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Chemotactic Cytokines (GRS)

Gordon Research Seminar

Emerging Perspectives on Chemokine Network Interactions and Functions

June 1 - 2, 2024

Chairs

and

University of Southern Maine

25 Bedford St.

Portland, Maine, United States

Venue and Travel Information

Conference Description

The Chemotactic Cytokines GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Chemotactic cytokines (chemokines) control a diversity of physiologic responses related to cell migration, immune cell functions, and others. This meeting is a forum to share perspectives on emerging concepts in chemokine biology, including chemokine structure, function and receptor interactions, atypical chemokine receptors, development of therapeutic strategies related to chemokines and their receptors, and their role in homeostasis and development, autoimmunity, cancer, and chronic inflammation.

Related Meeting

This GRS will be held in conjunction with the "Chemotactic Cytokines" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Biochemistry and Structural Biology of Chemokines and Their Receptors Discussion Leader:
3:45 pm - 4:00 pm	Introduction by Discussion Leader
4:00 pm - 4:10 pm	"The Role of Receptor Glycosylation and Tyrosine Sulfation in CCL2-Mediated CCR2 Signaling"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"GPR15LG Modulates Signaling Through CXCR4 and ACKR3"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Technologies to Study Chemokine-Directed Cell Migration Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 7:50 pm	"Dendritic Cells as Perivascular Gatekeepers for Immune Cell Entry into the Tumor Microenvironment"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"The Role of Lymphatic Recirculation of Stem-Like T Cells in Anti-Tumor Immunity"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"The Impact of Platelets on the Post-EC Phase of Neutrophil Migration Through Venular Walls During Inflammation"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:35 pm	"Investigating the Consequences of Duffy-Negative Phenotype in Homeostasis and Inflammatory Diseases Using a Novel Mouse Model"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	"Lymph Node Lymphangiogenesis Maintains Germinal Center Niche to Enhance Highly Functional Antibody Production Against Cutaneous Virus Infection"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"Controlling the Selectivity And Pharmacology of Chemokine Receptors Using Engineered Nanobodies"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"Translating Chemokine Principles to Practice"
9:20 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Chemokines in Cancer and Other Diseases Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:25 am	"ACKR2 Controls Macrophages and Bacterial Clearance in the Peritoneum"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"A Persistent Vascular Endothelial Inflammatory State Maintains Local Immune Surveillance in Skin Post Infection"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Coordinated Chemokine Expression Defines Macrophage Subsets Across Tissues"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Conventional Type 2 Dendritic Cells License FoxP3+ Regulatory T Cells in a Ccr4-Dependent Manner to Suppress Allergic Inflammation"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Vascular Heterogeneity Determines Leukocyte Transendothelial Migration Efficiency"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Site-Specific Processing of CXCL10 in Plasma and Synovial Fluid of Patients with Rheumatic Diseases"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"CCR2-Driven Monocyte Recruitment Post Radiotherapy Reduces Radiation-Induced Gut Toxicity"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Chemokines and Development of Therapeutic Applications Discussion Leader:
1:30 pm - 1:45 pm	Introduction by Discussion Leader
1:45 pm - 1:55 pm	"Mucosal Vaccination to Improve Immunity to SARS-CoV-2"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:10 pm	"Enhancing the Plasma Half-Life of Broad-Spectrum Chemokine Binding Tick Proteins by Fusion to XTEN"
2:10 pm - 2:15 pm	Discussion
2:15 pm - 2:25 pm	"Monocyte Derived DCs and Interstitial Macrophages in the Lung ... and Cancer"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Eric Alon

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI183301. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Chemotactic Cytokines

June 7 - 12, 2026

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