Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Biochemistry and Structural Biology of Chemokines and Their Receptors
Discussion Leader: Douglas Dyer (University of Manchester, United Kingdom)
3:45 pm - 4:00 pm
Introduction by Discussion Leader
4:00 pm - 4:10 pm
Lisa Verhallen (Katholieke Universiteit Leuven, Belgium)
"The Role of Receptor Glycosylation and Tyrosine Sulfation in CCL2-Mediated CCR2 Signaling"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Mirja Harms (Ulm University Medical Center, Germany)
"GPR15LG Modulates Signaling Through CXCR4 and ACKR3"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technologies to Study Chemokine-Directed Cell Migration
Discussion Leader: Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
Lukas Altenburger (Massachusetts General Hospital / Harvard Medical School, United States)
"Dendritic Cells as Perivascular Gatekeepers for Immune Cell Entry into the Tumor Microenvironment"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Ines Delclaux (New York University Langone Health, United States)
"The Role of Lymphatic Recirculation of Stem-Like T Cells in Anti-Tumor Immunity"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Tugce Cimen (Würzburg University, Germany)
"The Impact of Platelets on the Post-EC Phase of Neutrophil Migration Through Venular Walls During Inflammation"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Zoe Möller Ramon (Ludwig-Maximilians-University Munich, Germany)
"Investigating the Consequences of Duffy-Negative Phenotype in Homeostasis and Inflammatory Diseases Using a Novel Mouse Model"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Tenny Mudianto (New York Unversity Langone Health, United States)
"Lymph Node Lymphangiogenesis Maintains Germinal Center Niche to Enhance Highly Functional Antibody Production Against Cutaneous Virus Infection"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Roman Schlimgen (Medical College of Wisconsin, United States)
"Controlling the Selectivity And Pharmacology of Chemokine Receptors Using Engineered Nanobodies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Philip Murphy (National Institute of Allergy and Infectious Diseases, United States)
"Translating Chemokine Principles to Practice"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemokines in Cancer and Other Diseases
Discussion Leader: Adit Ben-Baruch (Tel Aviv University, Israel)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
Gillian Wilson (University of Glasgow, United Kingdom)
"ACKR2 Controls Macrophages and Bacterial Clearance in the Peritoneum"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Vanessa Cristaldi (New York University Langone, United States)
"A Persistent Vascular Endothelial Inflammatory State Maintains Local Immune Surveillance in Skin Post Infection"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Xin Li (Dartmouth College, United States)
"Coordinated Chemokine Expression Defines Macrophage Subsets Across Tissues"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jenny Mannion (Massachusetts General Hospital, United States)
"Conventional Type 2 Dendritic Cells License FoxP3+ Regulatory T Cells in a Ccr4-Dependent Manner to Suppress Allergic Inflammation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Merel Tebbens (AMC Medical Research B.V. , The Netherlands)
"Vascular Heterogeneity Determines Leukocyte Transendothelial Migration Efficiency"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Luna Dillemans (The Rega Institute for Medical Research, Belgium)
"Site-Specific Processing of CXCL10 in Plasma and Synovial Fluid of Patients with Rheumatic Diseases"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Nabina Pun (University of Manchester, United Kingdom)
"CCR2-Driven Monocyte Recruitment Post Radiotherapy Reduces Radiation-Induced Gut Toxicity"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Chemokines and Development of Therapeutic Applications
Discussion Leader: Andrew Luster (Massachusetts General Hospital, United States)
1:30 pm - 1:45 pm
Introduction by Discussion Leader
1:45 pm - 1:55 pm
Juliana Barreto de Albuquerque (Massachusetts General Hospital / Harvard Medical School, United States)
"Mucosal Vaccination to Improve Immunity to SARS-CoV-2"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Mikaela Bell (Monash University, Australia)
"Enhancing the Plasma Half-Life of Broad-Spectrum Chemokine Binding Tick Proteins by Fusion to XTEN"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Claudia Jakubzick (Dartmouth School of Medicine, United States)
"Monocyte Derived DCs and Interstitial Macrophages in the Lung ... and Cancer"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes