Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Remodeling Chromatin Structure
7:40 pm - 8:00 pm
"Chromatin Dynamics and Transcriptional Homeostasis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"A Neuron-Specific Histone Demethylase Complex Fine Tunes Neurodevelopment"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Mechanisms Underlying Heterochromatin Formation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Stability and Dynamics of Epigenetic Modifications"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Direct Observation of DNA Buffering on the Nucleosome During Chromatin Remodeling Under Single-Turnover Conditions"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Assembly, Replication and Repair
9:00 am - 9:20 am
"De Novo Heterochromatin Formation in the Mouse Genome"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Chromatin Domains and Epigenetic Inheritance"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Regulation of X Chromosome Inactivation in Humans"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Activation of Xist by an Evolutionarily Conserved Function of KDM5C Demethylase"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Molecular Basis of Epigenetic Switching"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanisms of Gene Silencing Downstream of Methylation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
General Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Histone and RNA Modifications
6:00 pm - 6:20 pm
"Modifications of RNA and Their Role in Cancer"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"A Phosphatase Module of the Integrator Complex Regulates Pausing and Elongation"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Human X Chromosome Reactivation: Structural and Molecular Dynamics During Human Pluripotent Reprogramming"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"DNA-Damage Induced Regulation of Rapid Chromatin Remodeling by Nuclear PARPs"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Exploring the Physical Genome"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosomes and Genome Architecture
9:00 am - 9:20 am
"Dynamics of Transcription and Chromatin Remodeling Proteins at Single Molecule Level"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Enhancer Function in the Context of the 3D Genome"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Unfinished Business: Nucleosome Remodeling and Assembly"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"MSL Complex Ensures Biallelic Gene Expression in Mammals"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Investigating How Homolog Organization Shapes Regulatory Programs Using Genomic and Single-Cell Approaches"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Transcription Factors as Sensors and Modifiers of Chromatin"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Single-Fiber Nucleosome Density Shapes Regulation by a Chromatin Remodeler"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Snapshots of Divergent Evolution Towards Sex Chromosome-Specific Gene Regulation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin, Metabolism and Physiology
6:00 pm - 6:20 pm
"From Transcriptional Pausing to Metabolism and Cancer: Lessons From SIRT6"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Acetylation and Metabolic Control"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Genome Organization in and Around the Nucleolus"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Mechanisms of Gene Silencing and Dosage Regulation During X-Chromosome Inactivation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Quantitative Impact of Chromatin Modifications on Transcription"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Phasic Transcriptional Repression Protects Genome Integrity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reprogramming and Regeneration
9:00 am - 9:20 am
"Mammalian Epigenetic Inheritance"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Nucleolar Chromatin-Based Control of Cell Fate in Early Development"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Distinct Dynamics and Function of H2AK119ub1 and H2K27me3 in Mouse Preimplantation Embryos"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Nucleosome Turnover Regulates Epigenetic Modifications of the Genome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Mechanisms of Chromatin Remodeling"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Epigenetics and Inheritance"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mechanisms of Epigenetic Regulation in Early Development"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin and Disease Mechanisms
6:00 pm - 6:20 pm
"SAGA Functions in Development and Disease"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Principles of Epigenetics and Chromatin in Development and Human Disease"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
"Chromatin Assembly Facilitates Transcription of the Hepatitis B Virus Oncogene HBX"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Long-Range Gene Regulations by Enhancers"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Dynamic Behaviour of Xist RNA in X Chromosome Inactivation"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Dynamics and Kinetics of Chromatin Organization and Transcription Regulation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Super Resolution Imaging of Transcription in Live Mammalian Cells"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Phase Separation of Polycomb-Repressive Complex 1 Is Promoted by a Chromatin Scaffold"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Loop Extrusion and Gene Regulation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Spatial Organization of Chromosomes Drives the Liquid- or Gel-like Dynamical Behavior of Chromatin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Hexasome Is the Preferred Substrate for the INO80 Chromatin Remodeling Complex, Allowing Versatility of Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanisms of Mitotic Chromosome Scaling During Xenopus Laevis Embryogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transcription and Post-Transcriptional Events
6:00 pm - 6:20 pm
"Establishment of Heterochromatin in the Early Embryo"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"An Evolutionary Advanced Mechanism of Gene Expression Control: the Regulation of SWI/SNF by the Histone Variant H2A.B"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Histone Modification Dynamics During Transcription Activation in Living Cells and Embryos"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Structural Basis of Nucleosome Retention During Transcription Elongation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Nutrient Signaling Through Histone Modifications"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure