The Mucociliary Interface: Exogenous and Endogenous Challenges

February 15 - 16, 2025

Chairs

and

Sheraton Fairplex Hotel & Conference Center

601 West McKinley Ave.

Pomona, California, United States

Venue and Travel Information

Conference Description

The Cilia, Mucus and Mucociliary Interactions GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Related Meeting

This GRS will be held in conjunction with the "Cilia, Mucus and Mucociliary Interactions" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Ciliary Interactions and Signaling Discussion Leaders: and
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:20 pm	"Interactions within the Mucociliary Clearance System"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cilia Dynamics: Assembly, Transport, and Motility Discussion Leader:
7:30 pm - 7:45 pm	"From DynAPs to Axonemes: Insights into Axonemal Dynein Transport"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Primary Ciliary Dyskinesia Patient-Specific Models to Study and Treat Ciliary Dysfunction"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"GLI-Full Journey in the Primary Cilium"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Establishment of PCD DNAI1 Mutant Patient-Derived Nasal Epithelial Cultures for the Evaluation of Ciliary Activities"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"FIVER (Fluorescent In Vivo Editing Reporter): A Multispectral Fluorescent Reporter of Diverse Genome Editing Outcomes In Vitro and In Vivo"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Investigating the Effects of Influenza A Protein PA-X on Cilia Morphology and Dynamics in an Air-Liquid Interface Model of Primary Human Cells"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Mucus Inside and Outside of the Lungs Discussion Leader:
9:00 am - 9:15 am	"Probing Treatment Impact on Rheology of Secreted Epithelial Mucus of Healthy and CF Tissues In Situ with a Nondestructive Microrheology Platform"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Investigating the Influence of Mechanical Stresses on Ciliary Dynamics Using Advanced In Vitro Airway Models"
9:30 am - 9:35 am	Discussion
9:35 am - 9:50 am	"Mucin Targeted Gene Therapy for Asthma"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Restoration of cilia motility via mRNA therapy in Primary Ciliary Dyskinesia"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Effect of Neutrophil Extracellular Traps on Mechanical Properties of Mucus"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Investigating the Role of HIF Transcription Factors and Inflammation in Hypoxic Airway Epithelia"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Elasticity promotes directional transport of Pseudomonas aeruginosa in native respiratory mucus"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Life After a Terminal Degree: Careers in Academia, Industry, and Beyond Discussion Leader:
1:30 pm - 1:45 pm	Introduction by Discussion Leader
1:45 pm - 2:15 pm	Panel Discussion Science in Industry, Academia, and Translation
2:15 pm - 2:30 pm	General Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL178268. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

This material is based upon work supported by the Air Force Office of Scientific Research under award number FA9550-25-1-0085. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the United States Air Force.

Conference Links

Conference History Cilia, Mucus and Mucociliary Interactions