Uniting NMR and Computational Approaches to Push the Frontiers of Dynamic Structure and Conformational Transitions Critical to Function and Dysfunction

The Gordon Research Conference on Computational Aspects of Biomolecular NMR provides a unique forum for the presentation and discussion of emerging methods at the intersection of experimental Nuclear Magnetic Resonance (NMR), computational methods and other complementary biophysical techniques.

NMR is one of the most versatile methods for the investigation of biomolecular systems, whether these are proteins, nucleic acids, glycans, membranes, or functioning cellular and in vivo systems. Computational approaches have long been a necessary component of NMR applications. In combination with other complementary biophysical methods, NMR and computation contribute to our understanding and diagnosis of function and disease, the development of therapeutics to combat disease, and characterization of increasingly challenging systems due to their size, dynamics, and complicated conformational behavior. The combined use of NMR and computational methods provides unique structural, dynamical and functional information to achieve these goals, and increasingly many other complementary methods and techniques are being integrated for a more comprehensive view. This GRC conference will bring together practitioners in NMR, computational structural biology and other complementary biophysical techniques for the purpose of generating new ideas and promoting collaborations in order to catalyze the next generation of integrative methods that will allow us to tackle ever more challenging systems.

The 2017 meeting will have sessions devoted to advances and applications in computational methods, and as applied in combination with NMR and other biophysical methods to push the frontiers of structural biology particularly in the areas of conformational transitions, intrinsically disordered systems and interactions, dynamics and drug design, conformational variability and challenges in structure determination. The prominent list of speakers, along with the small format of the conference, will provide unique opportunities for graduate students, postdocs, and both those in the field and new to this research area, to discuss their ideas. Extensive poster sessions, along with oral presentations chosen from the submitted poster abstracts, will facilitate this process.