Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: The Neurology of Consciousness: Lessons from Coma, Anesthesia, Sleep, Hypnosis, and Meditation
3:15 pm - 3:45 pm
"The Neurology of Consciousness: Lessons from Coma, Anesthesia, Sleep, Hypnosis, and Meditation"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Physiologically and Pathologically Induced Altered States: Sleep, Dreaming, and Disorders of Consciousness
5:30 pm - 5:40 pm
"Electroencephalographic Findings From a Phase 1 Trial Using Intravenous Methylphenidate to Promote Consciousness in Patients with Acute Traumatic Brain Injury"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"The Effects of Deep Brain Stimulation (DBS) Frequencies on the Thalamo-Cortical Network Interactions Under Anesthesia"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Demodulating Unconsciousness: Circuit and Metabolic Dynamics Under Propofol and Sevoflurane"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"The Reduction of Sleep-Like Perilesional Cortical Dynamics Underlies Clinical Recovery in Stroke"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Mapping Neural Aperiodic Activity Across Sleep Stages in Humans with Direct Intracranial Recordings"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"The Spectrum of Conscious Experiences During NREM Sleep: There is More Than What Meets the Eye"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Impacts of Objective Social Isolation on Social Dream Contents"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Inducing REM-Sleep Dreams of Specific Memories"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Pharmacologically Induced Altered States: Anesthesia and Psychedelics
9:00 am - 9:10 am
"General Anesthesia Reduces the Uniqueness of Brain Functional Connectivity Across Individuals, Species, and Modalities"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Structure-Based Discovery of GABAergic General Anesthetics Chemically Distant from Known Drugs"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Leveraging Dopaminergic Circuits to Reverse Diverse Anesthetics"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Reactivation of Layer 5 Extratelencephalic Anesthetic-Active Prefrontal Neurons Is Sufficient to Drive Natural Sleep"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Reversal of Propofol and Isoflurane Anesthesia, with Concurrent Restoration of Brain Dynamics, by Intravenous Administration of the Serotonergic Psychedelic 2,5-Dimethoxy-4-iodoamphetamine"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"EEG Signatures of the Psychedelic Experience Remain Under Anesthesia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"The Brain's Balancing Act: Measuring Integration and Segregation in Consciousness"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Functional Connectivity and Integration in Psychedelic, Sleep, and Sedated States"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Emerging Techniques and Insights in the Study of Altered States of Consciousness
1:30 pm - 1:40 pm
"Targeting Anesthetic Dream States Using EEG-Guided Propofol Infusions"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Rethinking Psychedelics: Development and Mechanistic Understanding of Non-Hallucinogenic Psychedelic Analogs"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Uncovering the Dynamics of Psilocybin in Human Neural Pain Circuits with Intracranial Neural Recordings"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"How Does Evolution Build a Brain? Lessons from Genetic Building Blocks"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes