Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: CRISPR/Personalized Medicine: Approaches for the Ocular Surface
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
"Precision CRISPR Genome Surgery for Imprecision Medicine"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Modeling of Limbal Stem Cell Differentiation Using Human Pluripotent Stem Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"3D-Printed ABCB5-Positive Stem Cells for the Treatment of Corneal Blindness"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Intrinsic Microbiome and Influences of Microbiota from Remotes Sites
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Ocular Surface Microbiome: Genomic Analysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Microbiome: Influence of Age/Ocular Surface Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Ocular Surface Immune Transcriptome and Tear Cytokines in Corneal Infection Patient"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Corneal Immunophenotype and Homeostasis in a Mouse Model of High Fat Diet"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Commensals and the Eye: The Good and the Bad"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"The Role of the NLRP3 Inflammasome in Pseudomonas aeruginosa Keratitis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Role of Butyrate in Maintenance of Ocular Surface Health"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Exosomes in Healthy and Diseased Ocular Surface
Session in memory of James Zieske and James Funderburgh.
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Regulation of Limbal Niche in Normal and Diabetic Cornea by Extracellular Vesicles"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Mesenchymal Stroma Cell Derived Exosomes for Corneal Repair"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Extracellular Vesicles for the Treatment of Corneal Scars"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Identification and Generation of Corneal Stem Cells and Their Use for Transplantation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Use of Stem Cells for Corneal Disease Models and Cell Therapy"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Marking, Isolating and Transplanting Limbal Epithelial Progenitor Cells: Information Gleaned from a Colorful Biosensor Mouse"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Investigating Chondroitin Sulfate Substrates for the Cultivation of iPSC-Derived Corneal Epithelium"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Limbal Derived Mesenchymal Stem Cells in Novel Extracellular Matrix-Mimetic Hydrogel in Corneal Wound Healing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Use of Small-Molecules in Modulating Limbal Stem Cell Function"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Stem Cell Tracking, Loss and Recovery in the Corneal Epithelium"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Exploring Limbal Stem Cell Hierarchical Organization Using Single-Cell RNA Sequencing"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transcriptomics and Proteomics: Corneal Cell Types and Changes in Disease
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Uncovering Novel Cell Types in Human Corneal Limbus Using Single-Cell Transcriptomics"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Leveraging Hundreds of Publicly Available Ocular Gene-Expression Datasets to Identify Novel Transcripts, Tissue and Temporal Gene Markers, and Provide a Community Web Resource"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Identifying Pathological Changes in Keratoconus Using a Multi-Omics Approach"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Multi-Omics Analyses of Microenvironment of Aqueous Humor and Corneal Endothelial Cells in Bullous Keratopathy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Corneal Neighbors Affecting Its Function: Conjunctiva, Meibomian and Lacrimal Glands
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Effect of Inflammation and Aging on Lacrimal Gland Function"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Increased Tear Cathepsin S Drives Ocular Surface and Lacrimal Gland Inflammation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The Role of Corneal and Conjunctival Epithelial Dendritic Cells in Seasonal and Perennial Allergic Conjunctivitis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Role of Primary Cilia-Mediated Signaling in Development and Regeneration of the Meibomian Glands"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Hyaluronan Regulates Meibomian Gland Morphogenesis and Homeostasis"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Conjunctival Goblet Cells Targets of Allergic and Specialized Pro-Resolving Mediators"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Corneal Sensory Nerve Activity Depends on the Presence of Resident Dendritic Cells at Basal Conditions"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Tools for Ocular Drug Delivery
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Modeling of Aniridia-Related Keratopathy and Identification of Novel Drugs for Potential Repurposing Treatment"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Strategies to Deliver Natural Compounds to the Ocular Surface"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
"Topical Application of Polymeric Nanomicelles in Ophthalmology"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:40 pm
"Gene Therapy to the Cornea"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Immunity and Inflammation in Ocular Surface Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Innate Immunity in Microbial Keratitis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Contributors to the Absence of a Bacterial Microbiome on the Healthy Cornea"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Differential Reponses of Tear-Film PMNs on Reactive Oxygen Species Generation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Increase of Glycocalyx Barrier in Cornea Epithelium via Toll-Like Receptor 3 (TLR3)"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Ocular Response to Infection"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Role of Macrophage Populations in Herpes Virus Ocular Infection"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Corneal Epithelial Dendritic Cell Density and Morphology After 3 Months of Overnight Orthokeratology and Rigid Contact Lens Wear Compared to No Lens Wear"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
From Discovery to Clinic: Drug Testing and Regulatory Issues
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"The Liquid and Bioengineered Cornea: Stem Cells and Matrix"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"From Discovery to Clinic: Commercialising Innovations for Corneal Cell and Tissue Therapies"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"A Novel Biomarker for Neuropathic Corneal Pain: From Bedside to Artificial Intelligence and Back"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"Engineering Growth Factors for Clinical Use in Corneal Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure