A Fresh Systems-Level Perspective on Manipulating Cyclic Nucleotide Signaling Pathways for Therapeutic Gain

The 3’,5’-cyclic adenosine monophosphate (cAMP) and 3’,5’-cyclic guanosine monophosphate (cGMP) pathways, which are regulated by cyclic nucleotide phosphodiesterases (PDEs), modulate a number of critical physiological processes. As such, targets within these signaling cascades have long been of high interest to drug discovery efforts.

The 2024 Gordon Conference on Cyclic Nucleotide Phosphodiesterases will present bleeding-edge research that is driving the field to reconceptualize the fundamental biology and therapeutic potential of targets within the cyclic nucleotide signaling cascades. State-of-the-art technological approaches that shed new light on the physiology of these cascades will be shared. Sophisticated molecular/biochemical mechanisms by which targets within these cascades may be manipulated for therapeutic gain will also be highlighted. Innovative research describing the therapeutic potential of various targets in the context of multiple diseases will also be explored. In this regard, a fresh systems-level approach will be taken, with a given session focusing on the same target in the context of different organs/diseases. By bringing together leaders and trainees in the fields of cancer, cardiology, immunology & inflammation, neurology/neuroscience/psychiatry, pulmonology, etc., the conference hopes to advance drug discovery efforts by stimulating deep discussion of the potential for efficacy versus side effects.

The conference will bring together an international community of seasoned investigators, emerging new leaders, and trainees from academia, pharma, and biotech to present talks and posters. Ample time will also be dedicated to social activities to facilitate networking and idea exchange. A Gordon Research Seminar (GRS) will be held in conjunction with this conference. Please join this wonderful community of engaged and supportive scientists to expand your collaborative networks, advance the field, and get inspired with your next great idea!