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Cyclic Nucleotide Phosphodiesterases (GRS)

Gordon Research Seminar

Novel Approaches, Technology and Therapeutic Targets in Cyclic Nucleotide Phosphodiesterase Signaling

June 9 - 10, 2018

Chairs

and

Jordan Hotel at Sunday River

27 Grand Circle

Newry, Maine, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Cyclic Nucleotide Phosphodiesterases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight current aspects of cyclic nucleotide phosphodiesterase signaling ranging from new insight into the regulation of and by PDEs, to the therapeutic potential of PDEs. This will also include novel technology to unravel the complexity of cyclic nucleotide PDE signaling.

Related Meeting

This GRS will be held in conjunction with the "Cyclic Nucleotide Phosphodiesterases" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: The Multifaceted Nature of cAMP Compartmentalization Discussion Leader:
3:45 pm - 4:20 pm	"Spatial Constraints of Adenylyl Cyclase Signaling"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Phosphodiesterases as Therapeutic Targets Discussion Leader:
7:30 pm - 7:45 pm	"Inhibition of Phosphodiesterase (PDE) 2 Reverses the Development of Experimental Heart Failure by Promoting NO/GC-1/cGMP Signaling"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Phosphodiesterase 2 Inhibition Activates the Na+/K+-ATPase and Prevents Ventricular Tachycardia"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Acute Enhancement of Cardiac Function by PDE1 Inhibition in the Dog and Rabbit Show Targeted cAMP Signaling Distinct from Beta-Receptor Agonism"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"The Role of PDE1C in Vascular Smooth Muscle Senescence and Abdominal Aortic Aneurysm"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Disentangling Which PDE4D Isoform to Target in Alzheimer's Disease"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Physiological Consequences and Comparative Pharmacology of Inhibiting Nematode Phosphodiesterase Activity"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Complexity of Phosphodiesterase Regulation in Cyclic Nucleotide Signaling Discussion Leader:
9:00 am - 9:15 am	"Compartmentalized cAMP Signalling via the PDE4-POPeye Protein Complex"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Changes in Cardiomyocyte cGMP Dynamics During Hypoxia/Reoxygenation"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Differential Influence of Phosphodiesterase 1C on Human Arterial Smooth Muscle Cell Migration and Invasion"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"The Role of PDE11A4 in Isolation-Induced Neuroinflammation"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"The Phosphodiesterase 4 (PDE4) Inhibitor Roflumilast Improves Remyelination in a Mouse Model for Multiple Sclerosis"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: How to Sell Your Story Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Experiences from Our Own Careers
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

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Conference History Cyclic Nucleotide Phosphodiesterases

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