Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Regulating Cytoskeletal Motors and Filaments
7:40 pm - 8:20 pm
"Mechanism and Regulation of Cytoplasmic Dynein"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Endgame: Assembly and Disassembly at Actin Filament Ends"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Biophysics of Motors and Mechanobiology
9:00 am - 9:20 am
"Biophysical Mechanisms Regulating Cardiac Contractility"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Kinesin and Dynein Mechanochemistry Underlying Bidirectional Transport"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Reconstitution of Self-Organizing Anaphase-Like Microtubule Networks"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Molecular Mechanisms for Steady Force Transmission During Clathrin-Mediated Endocytosis"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Biophysical Studies of Kinetochores, the Protein Machines That Orchestrate Mitosis"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Mechanical Architecture and Function of the Mammalian Spindle"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Chimeric Kinesins Reveal Pathways to Aneuploidy"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Giant Actin Bundles and Myosin Function in the Chemosensory Tuft Cell"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Transport in the Making: Co-Translational mRNA Trafficking by Dynein"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Cell Morphogenesis Across Scales: From Molecular Processes to Cellular Forces"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Active Roles for Filament Tracks
9:00 am - 9:20 am
"A Tale of Filament Ends: Mechanistic Insights into the Actin Turnover Cycle"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Actin Severing Promotes Motor-Independent Contractility Propelled by the Diffusible Crosslinker Anillin"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Role of Nucleotide and Amino Acid Substitutions in the Functions of the Cytoskeletal Tracks"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Regulation of Cytoskeletal Myosin II Organisation and Function by Tropomyosin Isoforms"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"SSNA1 Mechanically Reinforces the Damaged Microtubule Lattice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Microtubule Cartography: The Role of Microtubule-Associated Proteins in Defining the Cellular Landscape"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Motors and Tracks Beyond the Animal Cell
7:30 pm - 7:50 pm
"Engineer C-Terminal Kinesin Motors with Plus-End-Directed Processivity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Force Generation During Parasite Navigation and Invasion"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"How a Motor Protein Helps Build Better Microtubule Highways"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Roles of Tubulin Isotype Blend in Microtubule Dynamics, PTMs, and Motor Activity"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
When Motors Go Awry: Motors in Disease
9:00 am - 9:20 am
"High-Throughput Functional Profiling of MYH7 Variants in Genome-Edited Cardiomyocytes for Cardiomyopathy Risk Prediction"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"How Pathogenic Mutations Disrupt Kinesin Regulation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Functional Residuomics of Kinesin Motor Domains Reveals Pathogenic Signatures and Therapeutic Suppressor Pathways"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Fine-Tuning Hearing: Isoform-Specific Control of Hair Cell Mechanotransduction by Myosin 7a"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Development of First-in-Class Non-Muscle Myosin II Inhibitors"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Gas and the Brakes: Mechanisms of Motor Regulation
7:30 pm - 7:50 pm
"Mechanism and Regulation of Intraflagellar Transport Motors"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"The Regulation of Non-Muscle Myosin II by Acetylation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Roles and Regulation of Myosin V Adaptors"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Regulation and Membrane Interactions of Single Myosin Motors"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Structural Biology of Cytoskeletal Motors
9:00 am - 9:20 am
"Feeling the Load: How Myosins Tune Their Kinetics"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Myosin Under Strain: The Structural Basis of the Gated Gait in Myosin 5"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Capturing and Modulating Myosin in Motion"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Structural Basis of Dynein Transport Machinery Assembly and Regulation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Not Just Autoinhibition: How Kinesin Motors are Inhibited by Kinesin-Binding Protein"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emergent Physics of Motor-Filament Systems
7:30 pm - 7:50 pm
"Active Mechanics of the Mitotic Spindle"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Mechanistic Principles Underlying Unidirectional Motion in Biomolecular Motors: A Constructive Approach"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Short Talk Selected from Poster Abstracts
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Self-Organization of Microtubule Arrays Through the Interplay of Motor and Crosslinker Forces and Separation-Dependent Binding"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Brakes and Governors in Stable and Dynamic Actomyosin Rings"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure