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Diffraction Methods in Structural Biology

Gordon Research Conference

July 11 - 16, 2004
Chair
Vice Chair
Bates College
2 Andrews Road
Lewiston, Maine, United States
 Venue and Travel Information

Conference Description

The 2004 Gordon Research Conference on Diffraction Methods in Structural Biology will be a highly interactive meeting focusing on advances in methodology for macromolecular X-ray crystallography and other diffraction applications, with highlights of particularly significant structural results. All participants will be expected to contribute extensively to discussion, to present either a talk or a poster, and to attend the entire conference.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and check-in
6:00 pm Dinner
7:30 pm - 9:30 pmMOLECULAR COMPLEXES AND MEMBRANE PROTEINS
7:30 pm Discussion Leader: Alwyn Jones (Uppsala University)
Introductory comments
7:35 pm - 8:00 pmJohn Tesmer (University of Texas)
"A peripheral membrane complex of G protein-coupled receptor kinase 2"
8:10 pm - 8:40 pmSo Iwata (Imperial College London)
"Structure and mechanism of lactose permease from E. coli"
8:50 pm - 9:20 pmWayne Hendrickson (Columbia University)
"Interactions between human follicle stimulating hormone and its G-protein coupled receptor"
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pmPUSHING THE LIMITS OF SYNCHROTON TECHNIQUES
9:00 am - 9:15 am Discussion Leader: Elspeth Garman (University of Oxford)
Introductory comments
9:20 am - 9:50 amKeith Moffat (University of Chicago)
"Time-independent intermediate structures from time-dependent data"
10:00 am - 10:30 amCoffee Break / Photo
10:40 am - 11:10 amAlberto Podjarny (UPR de Biologie Structurale, Strasbourg)
"MAD and Native studies of aldose reductase-inhibitor complexes at subatomic resolution"
11:10 am - 11:40 amGebhard Shertler (MRC Cambridge)
"Structure of rhodopsin in a P31 crystal determined on a micro-focus beamline"
11:50 am - 12:20 pmAlexei Soares (Brookhaven National Laboratory)
"Three-beam interference is a sensitive measure of the efficacy of macromolecular refinement techniques"
12:30 pmLunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session I
6:00 pm Dinner
7:30 pm - 9:30 pmLONG WAVELENGTHS FOR PHASING
Discussion Leader: Andrew Leslie (MRC Laboratory of Molecular Biology)
7:30 pm - 7:50 pmManfred Weiss (EMBL-Hamburg)
"The use of longer X-ray wavelengths in protein crystallography"
8:00 pm - 8:20 pmZbigniew Dauter (NCI and Brookhaven National Laboratory)
8:30 pm - 8:50 pmB.-C. Wang (University of Georgia, Athens)
9:00 pm - 9:20 pmRaimond Ravelli (EMBL Grenoble)
"Short wavelengths for phasing"
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTECHNIQUES FOR MEDIUM-RESOLUTION STRUCTURE DETERMINATION
9:00 am - 9:15 amDiscussion Leader: Paul Adams (Lawrence Berkeley National Laboratory)
Introductory comments
9:20 am - 9:50 amAxel Brunger (HHMI and Stanford University)
"Structure of p97/VCP. Experiences at medium resolution"
10:00 am - 10:30 am Steve Ludtke (Baylor College of Medicine, Houston)
"Extending the limits of single-particle reconstruction - CryoEM at subnamometer resolutions"
10:40 am - 11:10 am Coffee Break
11:10 am - 11:40 amConstantina Bakolitsa (The Burnham Institute)
"Structure of vinculin"
11:50 am - 12:20 pmMichael Rossmann (Purdue University)
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pm Dinner
7:30 pm - 9:30 pmPHASING AND DENSITY MODIFICATION
7:30 pm - 7:40 pmDiscussion Leader: Eleanor Dodson (York University)
Introductory comments
7:40 pm - 8:05 pmRandy Read (Cambridge University)
"Phasing with maximum likelihood in Phaser"
8:15 pm - 8:40 pmPaul Emsley (York University)
"Clipper-based model building"
8:50 pm - 9:15 pmGerard Bricogne (Global Phasing)
"Progress with phase determination in difficult situations"
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:10 amMODEL-BUILDING AND REFINEMENT
9:00 am - 9:05 amDiscussion Leader: Victor Lamzin (EMBL Hamburg)
Introductory comments
9:05 am - 9:30 amThomas Ioerger (Texas A&M University)
"An automated system for model-building based on pattern recognition methods"
9:40 am - 10:05 amAnastassis Perrakis (Netherlands Cancer Institute)
"New algorithms and concepts for the new generation of ARP/wARP"
10:15 am - 10:40 am Garib Murshudov (York University)
10:40 am - 11:10 amCoffee Break
11:10 am - 12:30 pmAB INITIO METHODS
11:10 am - 11:20 amDiscussion Leader: Vladimir Lunin (Institute of Mathematical Problems of Biology RAS)
Introductory comments: "Ab-initio phasing starting from a low resolution"
11:20 am - 11:45 amPiet Gros (Bijvoet Center for Biomolecular Research, Utrecht)
"The potentials of conditional dynamics"
11:55 am - 12:20 pmAlexandre Urzhumtsev (Universite H. Poincare)
"Ab initio phasing: very low resolution - low resolution"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pm Dinner
7:30 pm - 9:30 pmDATA AND STRUCTURE ANALYSIS
7:30 pm - 7:35 pmDiscussion Leader: Gerard Kleywegt (Uppsala University)
Introductory comments
7:35 pm - 8:00 pmTodd Yeates (UCLA)
"New equations and recent trends in twinning and other crystal disorders"
8:10 pm - 8:35 pmThomas Schneider (FIRC Institute of Molecular Oncology)
"Coordinate uncertainties and structure comparison"
8:45 pm - 9:10 pmJane Richardson (Duke University)
"Easier ways to make your structures even better"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSOFTWARE DEVELOPMENT AND SUBSTRUCTURE DETERMINATION
9:00 am - 9:05 amDiscussion Leader: Thomas Schneider (FIRC Institute of Molecular Oncology)
Introductory comments
9:05 am - 9:30 amRalf W. Grosse-Kunstleve (Lawrence Berkeley National Laboratory)
"Architecture of the Hybrid Substructure Search in Phenix"
9:40 am - 10:05 amZbyszek Otwinowski (UT Southwestern Medical Center)
10:15 am - 10:50 am Charles Weeks (Hauptman-Woodward Institute)
"Automated substructure determination and phasing with BnP"
10:50 am - 11:20 am Coffee Break
11:20 am - 11:45 amCarmelo Giacovazzo (University of Bari)
11:55 am - 12:20 pmGeorge Sheldrick (University of Goettingen)
"Substructure determination from weak anomalous data"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 8:00 pmBUSINESS MEETING (VOTING FOR NEXT CO-CHAIR)
8:00 pm - 9:30 pmDYNAMICS AND DISORDER
8:00 pm - 8:05 pmDiscussion Leader: Todd Yeates (UCLA)
Introductory Comments
8:05 pm - 8:30 pmS. James Remington (University of Oregon)
"Time resolved excited state proton transfer and chromophore dynamics in fluorescent proteins"
8:40 pm - 9:05 pmGeorge Phillips (University of Wisconsin)
"Effects of crystal contacts on structure and dynamics of proteins"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 am Departure

Contributors

The chair would like to thank the following organizations for generous support:

Merck & Co.
Pfizer
GlaxoSmithKline
Rigaku/MSC
MarUSA

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