SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | MACROMOLECULAR STRUCTURES: PUSHING THE BOUNDARIES |
7:35 pm - 7:40 pm | Discussion Leader: Michael Rossmann (Purdue University, USA) |
7:40 pm - 8:25 pm | Doug Rees (Caltech/HHMI, USA)
"Adventures in membrane protein crystallography" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Kiyoshi Nagai (MRC -LMB, Cambridge, England)
"Architecture of the spliceosomal snRNPs: Interpreting a low resolution map using heavy atom markers" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CRYSTALLISATION AND THE DIFFRACTION EXPERIMENT |
9:00 am - 9:05 am | Discussion Leader: Bob Sweet (Brookhaven National Laboratory, USA) |
9:05 am - 9:40 am | Seth Harris (Genentech, San Francisco, USA)
"Acoustic Liquid Transfer: Applications in small volume crystallization" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:15am | Coffee Break / Group Photo |
10:15 am - 10:50 am | Todd Yeates (University of California at Los Angeles, USA)
"Identifying and overcoming lattice translocation disorders" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:35 am | James Holton (University of California at San Francisco / Lawrence Berkeley National Laboratory, USA)
"MLFSOM: simulating the diffraction experiment from first principles" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Gwyndaf Evans (Diamond Light Source, UK)
"Microcrystallography: Choosing your weapon" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RADIATION DAMAGE AND DATA COLLECTION STRATEGIES |
7:30 pm - 7:35 pm | Discussion Leader: Vivian Stojanoff (Brookhaven National Laboratory, USA) |
7:35 pm - 8:05 pm | Martin Weik (Institut de Biologie Structurale, Grenoble, France)
"Radiation damage in MX: what's new?" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Y. Zou Finfrock (Physics department, University of Washington, USA)
"Spatial dependence and mitigation of MX radiation damage by focusing" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9.25 pm | Marcus Mueller (Swiss Light Source, Paul Scherer Institut, Switzerland)
"Data collection strategies for single photon counting pixel detectors" |
9:25 pm - 9.30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SYNCHROTRON DEVELOPMENTS AND AUTOMATED DATA PROCESSING |
9:00 am - 9:05 am | Discussion Leader: Thomas Schneider (EMBL Hamburg, Germany) |
9:05 am - 9:40 am | Sean McSweeney (ESRF, Grenoble, France)
"Advanced sample evaluation and experiment planning" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Janet Smith (University of Michigan / GM/CA CAT, USA)
"Small and smaller beams for ordinary and extraordinary experiments at GM/CA CAT" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Graeme Winter (Diamond Light Source, UK)
"Automated data reduction: Xia2 and Chef" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Clemens Vonrhein (Global Phasing Ltd, UK)
"Automated (and non-automated) data processing with autoPROC" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | COMPLEMENTARY TECHNIQUES |
7:30 pm - 7:35 pm | Discussion Leader: Ana Gonzalez (Stanford Synchrotron Radiation Lightsource, USA) |
7:35 pm - 8:05 pm | Sriram Subramaniam (National Cancer Institute, USA)
"Visualizing cells and viruses at molecular resolution with 3D electron microscopy: Progress and challenges" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Tsutomu Matsui (Stanford Synchrotron Radiation Lightsource, USA)
"Recent advances in bio-SAXS: bringing back atomic-resolution structures into life" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Carrie Wilmot (University of Minnesota, USA)
"Linking single crystal spectroscopy to structure" |
9.25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRUCTURE SOLUTION AND REFINEMENT |
9:00 am - 9:05 am | Discussion Leader: Paul Adams (Lawrence Berkeley Laboratory, USA) |
9:05 am - 9:40 am | Randy Read (Cambridge Institute for Medical Research, University of Cambridge, UK)
"Using SAD data in Phaser" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Garib Murshudov (University of York, UK) |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Tom Terwilliger (Los Alamos National Laboratory, USA)
"Automated structure determination with PHENIX" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Ethan Merritt (University of Washington School of Medicine, USA)
"TLS models: There's more to this than just a nice R-factor" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | CHALLENGING PROBLEMS/MEMBRANE PROTEINS |
7:30 pm - 7:35 pm | Discussion Leader: Michael C. Wiener (Department of Molecular Physiology and Biological Physics, University of Virginia, USA) |
7:35 pm - 8:05 pm | Martin Caffrey (Membrane Structural and Functional Biology Groups, Trinity College, Dublin, Ireland)
"Membrane protein structure determination using crystallography and lipidic mesophases - Recent advances and successes" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Stephen White (University of California at Irvine, USA)
"Exploring membranes by neutron diffraction" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Hao Wu (Weill Cornell Medical College, USA)
"Heterogeneity, low solubility and low resolution: structural pursuit on the ternary Myddosome complex in Toll-like receptor signaling" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:25 am | TALKS SELECTED FROM POSTERS |
9:00 am - 9:05 am | Discussion Leader: Anastassis Perrakis (Netherlands Cancer Institute,
The Netherlands) |
9:05 am - 9:20 am | TBA (to be selected from posters) |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:40 am | TBA (to be selected from posters) |
9:40 am - 9:45 am | Discussion |
9:45 am - 10:00 am | TBA (to be selected from posters) |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | TBA (to be selected from posters) |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 12:30 pm | MAP IMPROVEMENT AND MODEL BUILDING |
10:55 am - 11:00 am | Discussion Leader: Anastassis Perrakis (Netherlands Cancer Institute,
The Netherlands) |
11:00 am - 11:35 am | Paul Emsley (University of Oxford, UK)
"Low resolution model building using COOT" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Johan Hattne (EMBL Outstation Hamburg, Germany / UT Southwestern Medical Centre, USA)
"Modelling nucleic acids with ARP/wARP" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FUTURE METHODS: FELs AND DIFFRACTION IMAGING |
7:30 pm - 7:35 pm | Discussion Leader: Ed Lattman (Hauptman-Woodward Medical Research Institute, Buffalo, USA) |
7:35 pm - 7:55 pm | Petra Fromme (Department of Chemistry and Biochemistry, Arizona State University, USA)
"Opportunities for membrane protein analysis with FELs - recent results from LCLS" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Anton Barty (Center for Free-Electron Laser Science, Germany)
"Single-particle imaging with pulsed hard-Xray lasers" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | John C.H. Spence (Arizona State University and Lawrence Berkeley Laboratory, USA)
"Femtosecond nanocrystallography of membrane proteins using LCLS" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |