Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Tuning the Behavior of Migrating Cells for Diverse Applications
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Migration of Phagocytes: From Fundamentals to Immunotherapy of Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Engineering Collective Cell Migration, One Cell at a Time"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Tissue Repair
9:00 am - 9:25 am
"Understanding the Directionality and Tissue Invasion Capacities of Macrophages"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"The Scaffold Protein CasL Regulates T Cell Migration by Restricting Membrane Blebbing"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Harnessing How Lymphocytes Self-Organize into Multicellular Machines"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Different Ways Through the Maze: Immune Cell Chemotaxis in Complex Environments"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Swarming and Trapping: LTB4 Gradients Shape Neutrophil Dynamics in Tissues"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Decision-Making During Cell Migration"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Cooperative Motility Emerges in Crowds of T Cells but Not Neutrophils"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Spontaneous Signal Generation by Excitable Ras Dynamics for Random Cell Migration"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathfinding and Navigation
6:00 pm - 6:25 pm
"LTB4 Signaling During Neutrophil Chemotaxis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"The Role of Migrasomes in Directed Cell Migration"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Directional Cell Migration Decisions in Multi-Cue Environments"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Galvanotactic Directionality of Cell Groups Depends on Group Size"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Internal Durotaxis and Asymmetric Shapes of Cell Clusters"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"New Mechanosensitive Axes During Collective Cell Migration in Vivo"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Large-Scale Synchronized Temporal Oscillation in Epithelial Collective"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Negotiating the Crowd: Tissue Mechanics and Cell Movement"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ Sculpting by Contact-Mesenchymalization"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"You Shall Not Pass! How Ectoderm Patterning Modulates Lateral Mesendoderm Migration in the Early Zebrafish Gastrula"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Mechanism of Mammary Gland Epithelial Directional Migration"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Tissue Fluidification in Pathophysiology: Contact Percolation Sets Phase Transition and Genetic Rewiring in Heterogenous Breast Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanics of Cell Shape and Polarity
6:00 pm - 6:25 pm
"Gradients of ER-PM Contacts Direct Cell Signaling and Cell Migration"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"A Molecular Atlas of the Lamellipodial Cell Motility Machinery"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Long Range Mutual Activation Establishes Rho and Rac Polarity During Cell Migration"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Maintaining Coherence in Single Cell and Collective Migration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Migration in the Context of Developing Tissues
9:00 am - 9:25 am
"Making Your Skin Crawl: Cell Migration in Confined Epithelial Spaces"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Real Time Imaging of Cell Migration During Tissue Repair"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Finding Fertile Ground: The Mechanism and Control of Mammalian Primordial Germ Cell Migration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"How Neurons Navigate in the Vertebrate Retina: A Matter of Processes and Attachments"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Images to Insights: Building Models of Cell Migration Mechanics from Microscopy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dynamics of Melanocyte Migration Across the Basement Membrane"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Zebrafish Trunk Neural Crest: An In Vivo Model to Understand Cell Migration Under Physiological Mechanical Compression"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cytoskeletal Dynamics and Force Generation
6:00 pm - 6:25 pm
"Associative Memory in Cancer Cells"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Overcoming Obstacles – How to Train T-Cells to Migrate in Dense Cancerous Tissues"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Actin Dynamics Sustains Spatial Gradients of Membrane Tension in Adherent Cells"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Regulating Force Transmission and Signaling from the ECM to the Nucleus"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Migration and the Metastatic Cascade
9:00 am - 9:25 am
"Eating and Walking- How Cancer Cells Fuel their Invasive Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cell and Tissue Transition States Regulating Collective Invasion and Metastatic Dissemination"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Mechanical Regulation of Metastasis by the Brain Vasculature"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Biomechanical Adaptations in Migrating Metastatic Cancer Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Plasticity of Breast Cancer Cell Migration in Response to Metabolic Challenge"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Self-Organizing Glycolytic Waves in the Plasma Membrane Fuel Cell Migration and Cancer Progression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Oncogenic PIK3CA H1047R Mutation Hacks Cell Communication to Induce Collective AKT/ERK Signaling Waves to Coordinate Breast Cancer Invasion/Proliferation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Diverse Modes of Cell Motility
6:00 pm - 6:25 pm
"Swimming in the Crowd: Drosophila Adipocytes on the Move"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"A Relative of the “Brain-Eating Amoeba” Crawls Quickly and Persistently through Confined Environments by Blebbing"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Dynamic Cytoskeletal Polarity Drives Oscillatory Migration of Cardiac Progenitors During Drosophila Heart Tube Formation"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Bioelectric Control of Motility in Single-Celled Eukaryotes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure