Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Tuning the Behavior of Migrating Cells for Diverse Applications
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Migration of Phagocytes: From Fundamentals to Immunotherapy of Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Engineering Collective Cell Migration, One Cell at a Time"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Tissue Repair
9:00 am - 9:25 am
"Understanding the Directionality and Tissue Invasion Capacities of Macrophages"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"The Scaffold Protein CasL Regulates T Cell Migration by Restricting Membrane Blebbing"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Harnessing How Lymphocytes Self-Organize into Multicellular Machines"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Different Ways Through the Maze: Immune Cell Chemotaxis in Complex Environments"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Swarming and Trapping: LTB4 Gradients Shape Neutrophil Dynamics in Tissues"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Decision-Making During Cell Migration"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Cooperative Motility Emerges in Crowds of T Cells but Not Neutrophils"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Spontaneous Signal Generation by Excitable Ras Dynamics for Random Cell Migration"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathfinding and Navigation
6:00 pm - 6:25 pm
"LTB4 Signaling During Neutrophil Chemotaxis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"The Role of Migrasomes in Directed Cell Migration"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Directional Cell Migration Decisions in Multi-Cue Environments"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Galvanotactic Directionality of Cell Groups Depends on Group Size"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Internal Durotaxis and Asymmetric Shapes of Cell Clusters"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"New Mechanosensitive Axes During Collective Cell Migration in Vivo"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Large-Scale Synchronized Temporal Oscillation in Epithelial Collective"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Negotiating the Crowd: Tissue Mechanics and Cell Movement"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ Sculpting by Contact-Mesenchymalization"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"You Shall Not Pass! How Ectoderm Patterning Modulates Lateral Mesendoderm Migration in the Early Zebrafish Gastrula"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Mechanism of Mammary Gland Epithelial Directional Migration"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Tissue Fluidification in Pathophysiology: Contact Percolation Sets Phase Transition and Genetic Rewiring in Heterogenous Breast Cancers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanics of Cell Shape and Polarity
6:00 pm - 6:25 pm
"Gradients of ER-PM Contacts Direct Cell Signaling and Cell Migration"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"A Molecular Atlas of the Lamellipodial Cell Motility Machinery"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Long Range Mutual Activation Establishes Rho and Rac Polarity During Cell Migration"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Maintaining Coherence in Single Cell and Collective Migration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Migration in the Context of Developing Tissues
9:00 am - 9:25 am
"Making Your Skin Crawl: Cell Migration in Confined Epithelial Spaces"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Real Time Imaging of Cell Migration During Tissue Repair"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Finding Fertile Ground: The Mechanism and Control of Mammalian Primordial Germ Cell Migration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"How Neurons Navigate in the Vertebrate Retina: A Matter of Processes and Attachments"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Images to Insights: Building Models of Cell Migration Mechanics from Microscopy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dynamics of Melanocyte Migration Across the Basement Membrane"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Zebrafish Trunk Neural Crest: An In Vivo Model to Understand Cell Migration Under Physiological Mechanical Compression"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cytoskeletal Dynamics and Force Generation
6:00 pm - 6:25 pm
"Associative Memory in Cancer Cells"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Overcoming Obstacles – How to Train T-Cells to Migrate in Dense Cancerous Tissues"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Actin Dynamics Sustains Spatial Gradients of Membrane Tension in Adherent Cells"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Regulating Force Transmission and Signaling from the ECM to the Nucleus"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Migration and the Metastatic Cascade
9:00 am - 9:25 am
"Eating and Walking- How Cancer Cells Fuel their Invasive Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cell and Tissue Transition States Regulating Collective Invasion and Metastatic Dissemination"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Mechanical Regulation of Metastasis by the Brain Vasculature"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Biomechanical Adaptations in Migrating Metastatic Cancer Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Plasticity of Breast Cancer Cell Migration in Response to Metabolic Challenge"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Self-Organizing Glycolytic Waves in the Plasma Membrane Fuel Cell Migration and Cancer Progression"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Oncogenic PIK3CA H1047R Mutation Hacks Cell Communication to Induce Collective AKT/ERK Signaling Waves to Coordinate Breast Cancer Invasion/Proliferation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Diverse Modes of Cell Motility
6:00 pm - 6:25 pm
"Swimming in the Crowd: Drosophila Adipocytes on the Move"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"A Relative of the “Brain-Eating Amoeba” Crawls Quickly and Persistently through Confined Environments by Blebbing"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Dynamic Cytoskeletal Polarity Drives Oscillatory Migration of Cardiac Progenitors During Drosophila Heart Tube Formation"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
"Bioelectric Control of Motility in Single-Celled Eukaryotes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure