Controlling Cancer by Exploiting Fundamental Knowledge of DNA Damage and Mutation

The 2018 Gordon Research Conference on DNA Damage, Mutation and Cancer is developed around the theme of exploiting fundamental knowledge to advance treatment and prevention. Rich and ever-increasing information is available on the specific mutations that are the molecular basis of cancer. Many mutations can be traced to specific types of damage to the DNA, while others arise from DNA replication errors or unknown causes. Technologies are being refined to determine the origins of these mutations, and monitor the accuracy and reproducibility of cancer genomic data. Biological and structural analyses can assess which mutations are functionally relevant. Specific mutations can confer vulnerabilities, making individual cancers more responsive to treatment with DNA damaging agents.

This conference is organized to stimulate constructive interactions among an international group of experts including academic scientists, researchers from industry, and practicing clinicians. Participants will discuss the most recent and unpublished advances resulting from the current convergence of knowledge. Sessions will focus on cancer-associated mutations, foundational principles, current and developing cancer treatments based on DNA repair capability, new targets, DNA repair inhibitors and resistance, and insights into mutation and cancer from model systems.

The meeting takes place in a relaxed environment as discussions begin over breakfast, continue during the afternoon and extend into the evening through convivial gatherings after each session. Most attendees will present posters in very active discussion sessions. The program will include times for short talks to be selected from poster abstracts. For the second time, the conference will be preceded by a 1.5 day Gordon Research Seminar (GRS), to foster involvement at the graduate student and postdoctoral level. Planned by and for trainees, it will provide an opportunity for junior researchers to present their work in a supportive, interactive environment. Time will also be devoted to career and funding planning.