Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Replication Gaps in Signaling, Repair and Disease
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
"Mind the Gap – Daughter-Strand Gaps as Sites of Damage Bypass and Damage Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"The Impact of Single-Strand Break Repair on Transcription, Replication, and Disease"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Checkpoint Responses
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functions of Biomolecular Condensates Assembled in Response to DNA Damage"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Checking the Completion of DNA Replication at the S/G2 Transition"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Processing DNA Damage During Mitosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
"Molecular Switches in Antibody Gene Diversification"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"ATR Kinase Inhibitors Induce Thymineless Death in CD8+ T Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Base Excision Repair Mediated Regulation of the Replication-Stress Induced Intra S-Phase Checkpoint"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Aberrant Activity of the APOBEC3A Cytidine Deaminase Causes Genome-Wide Indels and Altered DNA Methylation"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Structures Engaging Repair vs. Bypass Mechanisms
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Two Interaction Sites Between XPA and RPA Sculpt the Precision Complex in Human Nucleotide Excision Repair"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genome Damage and Mutations Arising from Persistent Ribonucleotides in DNA"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"DNA End Manipulation by Pol Theta"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"RAD51 Paralog Function in DNA Damage Tolerance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Single-Molecule Insights into Stressed DNA: Supercoiling, Secondary Structures and Topological Problems"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair, Replication and Cancer Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Impact of Lagging Strand ssDNA Gaps on Replication Fork Protection and Genomic Stability"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Catalytically Inactive PARP2 Blocks Nick Repair During Replication and Cause Lethal Anemia in Mice"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality with BRCA Deficiency"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Linking DNA Replication for Dynamics with Chemotherapy Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Pathways that Defy DNA Under-Replication"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Blocks versus Breaks: Cancer and Toxicity Pivot Depending on Aag Levels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"High-Throughput Screening Strategy Identifies Novel Regulator of Replication Stress Response"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosomal Dynamics, DNA Damage Signaling and Immune Responses
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Mechanism of Site-Specific Ubiquitin Removal in the Fanconi Anemia Pathway"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Message in a Small Extracellular Vesicle: An Unexpected Cargo Informs Innate Immune Cells About Cancer Cell DNA Damage"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Signatures of TGFß Competency and DNA Repair Predict Response to Anti-PD1 and Anti-PDL1 Therapies"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"New Insights Into Innate Immune Sensing During Tumorigenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Regulation of APOBEC3A Mutagenesis and Inflammation by the DNA Damage Response"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication, Collisions and Recovery
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Causes and Consequences of Replication Stress"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Landscapes: Implications for Genome Instability Mechanisms"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"When Repair Accidents Lead to DSB’s"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Epigenetic Control of G Quadruplex DNA"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Molecular Mechanisms in Transcription-Coupled DNA Repair"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Mechanisms of DNA Repeat Expansions: From Yeast to Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Uracil Excision and Abasic Site Accumulation Dictate Stalled Fork Stability in BRCA2-Deficient Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"BRCA1 Mutations and Polymerase Theta Addiction"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
CRISPR Screens to Gene Editing in Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Transforming Medicine: In Vivo and Ex Vivo Therapeutic Gene Editing"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Identifying Genetic Interactions for FA Through Genetic Screens"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Mapping the DNA Repair Processes that Enable CRISPR-Based Genome Editing"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Mechanism of DNA End Sensing by the MRE11 Complex: Implications for CRISPR-Based Genome Editing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Synthetic Lethality for Platinum-Induced DNA Damage Using CRISPRi Screens and Nanoparticle Delivery"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer, Aging and Neurodegeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genome Stability in Aging, Inheritance and Disease: An Organismal Perspective from C. elegans"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Endogenous DNA Damage as a Driver of Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Persistent Activation of the DNA Damage Response in LRRK2-Related Parkinson’s Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"The DNA Damage Response in Senescent Cells – Impacts on Genome Integrity, Aging and Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Extrachromosomal DNA: An Emerging Hallmark in Human Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The Processing of 8-Oxoguanine at Telomeres Promotes Cellular Senescence"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"DNA Damage-Based Mechanisms and Therapeutics for Age-Relative Neurodegenerative Diseases"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomic Instability and Emerging Targets for Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Linking RNA Processing Defects and Genome Integrity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Replication Stress as a Potential Driver of Clonal Hematopoiesis in 9/11 Firefighters"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Expanding the Scope of DNA Repair Factors - Novel Roles and Applications"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Exploring the Interface Between the Mtp53-PARP Axis and DNA Replication Regulation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Translation to Clinical Trials: How Do We Accelerate Progress?"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure