Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: DNA Repair Mechanisms and Disease
7:40 pm - 8:25 pm
"Mechanisms of DNA Repair in Three-Dimensional"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Two Faces of DNA Polymerases: Protecting Genomes and Causing Mutations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
End Joining Mechanisms and Cancer Therapeutics
9:00 am - 9:20 am
"Role of Disorder in NHEJ Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Senataxin and DNAPKcs Redundantly Promote NHEJ-Mediated RAG DSB Repair During V(D)J Recombination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Defining the Role of Chromosomal Break End Synapsis Factors in Blunt DSB EJ"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Targeting the DDR in Cancer Therapy"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"The Last Poorly Understood DNA Repair Pathway: Now Better Understood?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"The Unexpected Tale of Ku80 Tail"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Identification of the Main Barriers to Ku Accumulation in Chromatin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural Insights into the DNA Damage Response
7:30 pm - 7:50 pm
"Structural Basis of DNA Double-Strand Break Repair by NHEJ"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Quo Vadis, NEIL DNA Glycosylases? Functional Roles, Lesion Search, and Cancer Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Last Stop on the Road to Base Excision Repair: Nick Sealing by DNA Ligase"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Structural Characterization of Nucleotide Pool Regulation and Nucleotide Analogue Degradation by House-Keeping Enzyme SAMHD1"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mutations and Deregulation of the DNA Damage Response and Cancer
9:00 am - 9:20 am
"Mechanisms of Genomic Instability in Mammalian Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Targeting DNA Damage Repair in Ovarian Cancer with Epigenetic Drugs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Acquired Treatment Resistance in Homologous Recombination Deficient Ovarian Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Targeting DNA Repair Defects in Hereditary Breast Cancer: Clinical Updates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"DNA Damage Repair and Cancer through the Lens of the Host"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The SMC5/6 Complex is Required for Maintenance of Genome Integrity Upon APOBEC3A-Mediated Replication Stress"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Exploiting DDR Defects in Glioma via Small Molecule DNA Modifiers"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Replication and Cancer Therapy
7:30 pm - 7:50 pm
"Sources of Endogenous DNA Damage in Tumorigenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Leveraging the Gap Vulnerability in BRCA Deficient Cells to Combat Chemoresistance"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"High-Throughput Mapping of Sister Chromatid Exchange and Other Structural Variation Events with Single-Cell Sequencing"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Examination of Genetic and Environmental Factors that Promote Genome Instability and Cancer Initiation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Inactive Parp2 Causes Lethal Anemia in vivo"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The DNA Damage Response and Chromosomal Rearrangements
9:00 am - 9:20 am
"Mechanisms of DNA Double-Strand Break Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Repetitive Sequences: Drivers of Genomic Instability"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Investigating the Chromosomal Instability Signature Induced by LINE-1 Retrotransposition"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Structure of DNA Ends and Repair at Collapsed Forks"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"BLM Helicase Unwinds Lagging Strand Substrates to Assemble the ALT Telomere Damage Response"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Synthetic Lethality in BRCA-Mutated Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Pathological Activation of a Genome-Protective DNA Repair Pathway Induces Chromothripsis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Genome Maintenance
7:30 pm - 7:50 pm
"DNA Structure-Induced Genetic Instability in Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Regulation of Homologous Recombination Following Replicative Damage"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"The Role of DNA Discontinuities and ATP in Promoting MutLalpha Endonuclease Activity in DNA Mismatch Repair"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Investigating Break-Induced Replication in Mammalian Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"RAD51 Paralogs Travel with the Replicative Helicase to Bypass Alkylation-Induced DNA Damage"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genome Stability in the Brain and Aging
9:00 am - 9:20 am
"Delineating Topoisomerase Induced DNA Breaks as a Disease Etiology in the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Somatic Mutation in Aging and Neurodegeneration Revealed by Single Cell DNA Sequencing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"AXL-WRNIP1 Promotes Therapy Resistance and Metachronous Brain Metastasis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Timing Transition Region Fragile Sites in Neural Progenitor Cells"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Neuronal DNA Double-Strand Breaks Lead to Genome Structural Variations and 3D Genome Disruption in Neurodegeneration"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Neuronal DNA Repair and Aging"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ultra-High Fidelity Profiling of the Single-Strand Origins of Mutations"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Immune Signaling
7:30 pm - 7:50 pm
"Translating DNA Damage Response Therapeutics with Radiotherapy to Improved Anti-Tumor Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Molecular Basis of Lesion Recognition in Transcription: Coupled Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Immune Sensing of DNA Damage During Tumorigenesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mechanisms Underlying Anti-Metabolite Induced Innate Immune Signaling"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Heat Shock Protein DNAJA2 Regulates Transcription-Coupled Repair, Mitotic Division and Cancer Therapy"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure