Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Molecular Mechanisms to Clinical Trials
Discussion Leader: Valakunja Nagaraja (Indian Institute of Science, India)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
Sue Jinks-Robertson (Duke University Medical Center, United States)
"Mutation Signatures Associated with Topoisomerase Activity"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Yves Pommier (National Institutes of Health, United States)
"Poisoning the Magicians of the Genome"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Topoisomerases as Targets for Antimicrobial Agents
Discussion Leader: Anthony Maxwell (John Innes Centre, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Alexandra Aubry (Cimi-Paris / Sorbonne Universite / NRC for mycobacteria, France)
"What Can DNA Gyrase Assays Tell Us About Resistance to Fluoroquinolones in Mycobacterium tuberculosis ?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
Pan Chan (GlaxoSmithKline, United States)
"Discovery and Mode of Action of Gepotidacin, a Novel, First in Class, Triazaacenaphthylene Bacterial Topoisomerase Inhibitor"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Neil Osheroff (Vanderbilt University School of Medicine, United States)
"A Mechanistic Approach to Overcoming Fluoroquinolone Resistance"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Hannah Klein (New York Grossman University School of Medicine, United States) and Yuk-Ching Tse-Dinh (Florida International University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Processing of Topoisomerase Adducts
Discussion Leader: Hannah Klein (New York Grossman University School of Medicine, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Robert Van Waardenburg (University of Alabama at Birmingham, United States)
"Tyrosyl-DNA Phosphodiesterase I: From Structure-Function Analysis to Drug Target Strategies"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Ebba Kurz (University of Calgary, Canada)
"Novel Insights into the Role of TOP2B in the Cellular Response to DNA Damage"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Topology and DNA-Topoisomerase Interactions
Discussion Leader: David Levens (National Cancer Institute, NIH, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Chongyi Chen (National Cancer Institute, NIH, United States)
"Probing Genome-Wide DNA Supercoiling Patterns in Human Cells"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
Laura Baranello (Karolinska Institutet, Sweden)
"Targeting Topoisomerase Regulation During Transcription is a New Strategy to Affect Tumor Progression"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Thomas Nicholls (Newcastle University, United Kingdom)
"The Role of TOP3A in Human Mitochondrial DNA Maintenance and Mitochondrial Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ariel Afek (Weizmann Institute of Science, Israel)
"Impact of Structural Perturbations on Protein-DNA Interactions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modeling DNA Topoisomerases and Topology
Discussion Leader: Tamar Schlick (New York University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Md. Abul Hassan Samee (Baylor College of Medicine, United States)
"Considering DNA Sequence-Dependent Shapes for Genome Mining"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Parth Rakesh Desai (National Institutes of Health, United States)
"Coarse-Grained Simulations of DNA Plectoneme Localization at Base-Pair Mismatches"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Maduni Ranasinghe (University of Lethbridge, Canada)
"Partial Specific Volume and the Ratio of the Sedimentation to the Diffusion Coefficients Remain Constant Across DNA Minicircle Topological Changes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
DNA Topology and Topoisomerases at the Single Molecule Level
Discussion Leader: Alice Pyne (The University of Sheffield, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Zev Bryant (Stanford University, United States)
"Physical Mechanisms by Which Topoisomerases Convert Chemical Energy into Mechanical Work"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Graeme King (University College London, United Kingdom)
"How Topoisomerases Regulate DNA Topology and How DNA Supercoiling Alters DNA-Protein Interactions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Michelle Wang (Cornell University, United States)
"How DNA Motor Proteins Collide and Navigate Through Roadblocks and DNA Topology During Transcription and Replication"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Topoisomerases and DNA Topology in Cancer Chemotherapy
Discussion Leader: John Nitiss (University of Illinois at Chicago, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Junjie Chen (The University of Texas MD Anderson Cancer Center, United States)
"Cellular Responses to Topoisomerase II Poisons"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
William Gmeiner (Wake Forest School of Medicine, United States)
"TS/Top1 Dual Targeting by CF10 Results in Differential Dependence from CPT on PARG/PARP1/Tdp1 Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Topoisomerases as Cellular Poisons and Essential Enzymes
Discussion Leader: Matthew Schellenberg (Mayo Clinic, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Nayun Kim (University of Texas Health Science Center at Houston, United States)
"Functional Consequences of Topoisomerase I Interaction with G4 DNA"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
Yuh-Hwa Wang (University of Virginia School of Medicine, United States)
"Endogenous DNA Fragility: Investigating its Mechanism and as a Cancer Risk Assessment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Caroline Austin (Newcastle University, United Kingdom)
"Structure and Function of Type II Topoisomerase"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Topoisomerase Structure and Function
Discussion Leader: Valerie Lamour (Institut de Génétique et de Biologie Moléculaire et Cellulaire , France)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
James Berger (Johns Hopkins University School of Medicine, United States)
"Structural Considerations of DNA Topology and DNA Topoisomerases"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Nei-Li Chan (National Taiwan University, Taiwan)
"Structural Basis for the Assembly of Type IIA Topoisomerase DNA Cleavage/Religation Center"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure