| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Targeting Type II Topoisomerases |
| Discussion Leader: Anthony Maxwell (John Innes Centre, United Kingdom) |
| 3:45 pm - 4:15 pm | Katie Aldred (University of Evansville, USA)
"E. coli Gyrase: Interactions with Quinolones" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cellular Roles of Topoisomerases and Their Interactions |
| Discussion Leader: Robert Van Waardenburg (University of Alabama at Birmingham, USA) |
| 7:30 pm - 7:50 pm | Sarmistha Guha (Indian Institute of Science, India)
"Consequences of Perturbing DNA Gyrase Expression: Effect on Mycobacterial Growth, Physiology and Gene Regulation" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Kevin Lang (University of Washington, USA)
"Type II Topoisomerases Resolve Replication-Transcription Conflicts" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Jenna Lieberman (Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Spain)
"Regulation of TDP2 Function by SUMO Interactions" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | David Ontoso (Memorial Sloan Kettering Cancer Center, USA)
"Repair of Topoisomerase II-Induced DNA Double-Strand Breaks" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Topoisomerase Structure, Function and Drug Interactions |
| Discussion Leader: Roketa Sloan (St. Jude Children's Research Hospital, USA) |
| 9:00 am - 9:20 am | Rachel Ashley (Vanderbilt University, USA)
"Twists and Turns:
Recognition of DNA Topology by Bacterial Type II Topoisomerases" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Thomas Germe (John Innes Centre, United Kingdom)
"New Allosteric Inhibitors of DNA Gyrase Reveal a Stepwise Re-Ligation Mechanism" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Elizabeth Gibson (Vanderbilt University, USA)
"'Mycobacterium Gyrase Inhibitors' (MGIs): A Novel Class of Gyrase Poisons" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Lorena Infante (Vanderbilt University, USA)
"'Oligonucleotide-Topoisomerase
Inhibitors' Enhance Site-Specific DNA Cleavage Mediated by Human Type II
Topoisomerases" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Panel |
| This Mentorship session will be a career question and answer session with panelists from industry and academia. |
| Discussion Leader: Mary-Ann Bjornsti (University of Alabama at Birmingham, USA) |
| 1:30 pm - 1:35 pm | Introduction by Discussion Leader |
| 1:35 pm - 2:25 pm | Panel Discussion |
| "Our Future in Topoisomerase Research" |
|
- Alison Howells (Inspiralis Limited, United Kingdom)
- Yves Pommier (National Cancer Institute, NIH, USA)
- Lynn Zechiedrich (Baylor College of Medicine, USA)
- Katie Aldred (University of Evansville, USA)
- Anthony Maxwell (John Innes Centre, United Kingdom)
- Robert Van Waardenburg (University of Alabama at Birmingham, USA)
|
| 2:25 pm - 2:30 pm | Closing Remarks |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
