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DNA Topoisomerases in Biology and Medicine (GRS)

Gordon Research Seminar

Mechanisms, Interactions, and Roles of Topoisomerases in Origin and Treatment of Human Disease

July 28 - 29, 2018

Chairs

and

Mount Holyoke College

50 College Street

South Hadley, Massachusetts, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on DNA Topoisomerases in Biology and Medicine is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of the 2018 GRS will be to highlight the future of DNA topoisomerase research. It will address the new roles and interactions that DNA topoisomerases are being shown to have, as well as research on novel inhibitors. We hope to provide an opportunity to see what our own futures in topoisomerase research may be, as well as, how to go about establishing a career in the topoisomerase field.

Related Meeting

This GRS will be held in conjunction with the "DNA Topoisomerases in Biology and Medicine" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Human and Bacterial Type II Topoisomerases: Drug Interactions and Roles in Transcription Discussion Leader:
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:05 pm	"Polyamine-Containing Etoposide Derivatives as Poisons of Human Type II Topoisomerases: Differential Effects on Topoisomerase IIα and IIβ"
4:05 pm - 4:10 pm	Discussion
4:10 pm - 4:25 pm	"Reiterative Transcription and DNA Topology Join Hands for gyr Regulation in Mtb"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Characterization of Type II Topoisomerases and Topoisomerase-Related DNA Damage Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 7:55 pm	"Identification of New Topoisomerases VIII"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"5' Tyrosyl-DNA Phosphodiesterase 2 (TDP2) and Its Relevance to Topoisomerase Dependent DNA Damage"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"TDP1/TOP1 Activity Ratio as a Predictive Indicator for the Response of Glioblastoma Cancer Cells to Irinotecan Treatment"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Topoisomerase II Inhibitors-Induced Lesions: At the Crossroads Between NER and DSB Repair Pathways"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"The Dynamics of Topoisomerase II During Meiotic Prophase"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Genome Organization as Driver of Genome Instability"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Keynote Session: Topoisomerase I Structure and Function This session will focus on type I topoisomerases and will include presentations by our keynote speakers and by trainee speakers. Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Reaching for the TOPo (and Beyond): An Unexpected Journey"
9:35 am - 9:40 am	Discussion
9:40 am - 10:05 am	"The Stability of G4 DNA-Forming Genomic Loci Is Dependent on the Activity of Topoisomerase I"
10:05 am - 10:10 am	Discussion
10:10 am - 10:25 am	"Direct Observation of Type IA Topoisomerase Gate Opening"
10:25 am - 10:30 am	Discussion
10:30 am - 10:45 am	"Deciphering the Functional Requirement of Zinc Finger Motif(s) in Helicobacter pylori Topoisomerase I Catalysis"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Making It in a Topo World (and Other Stories of Success and Failure) Discussion Leader:
1:30 pm - 1:35 pm	Introduction by Discussion Leader
1:35 pm - 2:25 pm	Panel Discussion Faculty Q&A: Career Development
2:25 pm - 2:30 pm	Closing Remarks
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Rogers Family Charitable Foundation

Conference Links

Conference History DNA Topoisomerases in Biology and Medicine

Registration Fees Additional Fee Info

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