Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Strategies for Non-Viral Vectors Targeting Organs Beyond the Liver
Discussion Leader: Tetsuhiro Harimoto (Harvard University, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Gaurav Sahay (Oregon State University, United States)
"Strategies for Non-Viral Vectors Targeting Organs Beyond the Liver"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Leveraging Physicochemical Properties for Drug Delivery
Discussion Leader: Marshall Padilla (University of Pennsylvania, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
Katherine Vaidya (University of Minnesota, United States)
"Pooled Screening of Nanoparticles Using an Integrated, Mass Spectrometry-Based Barcoding Approach"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Rachel Young (Rowan University, United States)
"Hypoxia-Responsive Lipid Nanoparticles to Increase Nucleic Acid Delivery to the Preeclamptic Placenta"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Feyisayo Eweje (Massachusetts Institute of Technology, United States)
"Self-Assembling Protein Polymer Nanoparticles for Cytosolic Delivery of Therapeutic Macromolecules"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Julien Couture-Senecal (University of Toronto, Canada)
"Enhancing the Biodegradability of Ionizable Lipids in mRNA Vaccines Can Balance Their Inflammatory and Adjuvant Properties"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Souvik Ghosal (Cornell University, United States)
"Lipid Nanoparticle-mediated Delivery of Peptide-based Degraders Enable Improved Targeted Protein Degradation"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Harnessing Biology: Endogenous Targeting Strategies
Discussion Leader: Christina Cortez-Jugo (The University of Melbourne, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Anthony Omole (University of California, San Diego, United States)
"Comparative Immuno-Analysis for Drug Development: A Tale of Two Plant Viruses"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Sydney Wimberley (Georgia Institute of Technology, United States)
"Self-Assembling Protein Nanocages as an Influenza Vaccine for Older and Immunosuppressed Populations"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Alice Spadea (MPI-CBG, Germany)
"Deciphering Endosomal Escape: Insights into Lipid Nanoparticle-Endosomal Membrane Interactions and RNA Release for Enhanced Delivery"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Lin Di (Case Western Reserve University, United States)
"Cargo-Less Nano-Immunometabolic Therapy for Chronic Cardiac Fibrosis in Heart Failure"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Nishta Krishnan (UCSD, United States)
"A Novel Modular Strategy to Augment Functionality of Cell Membrane-Coated Nanoparticles"
10:45 am - 10:55 am
Discussion
10:55 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Transitions into Academia, Industry, and Beyond
Discussion Leader: Nicholas Lamson (Massachusetts Institute of Technology, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Transitions into Academia, Industry, and Beyond
Filipe Almeida (Nature Biomedical Engineering, Germany)
Michael Mitchell (University of Pennsylvania, United States)
Sanyogitta Puri (NovoNordisk, United States)
Simone Douglas-Green (Georgia Tech and Emory University, United States)
Laura Sepp-Lorenzino (Intellia Therapeutics, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes