Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Bridging Modern Technologies with Foundational DMPK Principles to Develop Improved Therapeutics
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Biochemistry to Organic Chemistry in Drug Metabolism"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges and Solutions for Characterization of Non-CYP Mediated Metabolic Pathways
9:00 am - 9:30 am
"Differential WIN18,446-Induced Inhibition of Human ALDH1A1 and ALDH1A2"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Unveiling the Role of Hydrolases in Drug Development and Precision Pharmacotherapy"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Targeting GSTs in Lung Injury"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Optimization of Metabolism in Macrocyclic Peptide Drug Discovery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Understanding the Regulation and Expression of Drug Metabolizing Enzymes
7:30 pm - 7:55 pm
"Atypical Regulation of CYP1B1 in Hepatic Stellate Cell Activation and Liver Fibrosis"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Lost in Translation: Interpreting Enzyme Down-Regulation in Induction Testing with Human Hepatocyte Culture Systems"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Inflammation-Driven Regulation of Drug Metabolizing Enzymes and its Clinical Implication"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microphysiological Systems as Models of Disease and DMPK
9:00 am - 9:30 am
"Regulatory Acceptance of Human on a Chip Systems for Efficacy, Safety and DMPK Studies"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Systemic Modeling of Human Skeletal Metastasis Using the InterOrgan Microphysiological System"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Integrating In Vitro and In Silico Models for Subcutaneous Drug Delivery and Biodistribution"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Integrating Complex In Vitro Model Contexts of Use with Fit-for-Purpose Strategies for Translational Impact"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Current Progress in Biotransformation Research and Metabolite Identification Techniques
7:30 pm - 7:55 pm
"Accelerator Mass Spectrometry for the Support of Microtracer Studies at Boehringer-Ingelheim: Insights to Technology, Applications and Strategies in State-of-the-art Drug Development"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"The Evolving Role of 19 F qNMR in Drug Metabolism Studies from Discovery Through Development"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Applications for Advanced Hepatocyte Models in Metabolite Profiling"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Harnessing the Power of Transporters to Develop Improved Therapeutics
9:00 am - 9:30 am
"The Risk and Benefits of Manipulating Tyrosine Kinase Regulation of Solute Carriers"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Expanding the Genetic Code to Study the Structure, Function and Regulation of the Human Apical Sodium-Dependent Bile Acid Transporter, ASBT"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Utility of Lysosomal Transporters as Gates for Drug Entry into the Cytoplasm"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Hepatic Uptake Transport of Oligonucleotide Drugs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Short Talks Selected from Poster Abstracts
7:30 pm - 7:45 pm
Short Talk Selected from Poster Abstracts
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Short Talk Selected from Poster Abstracts
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Challenges and Opportunities in ADME Investigations of Novel Therapeutic Modalities
9:00 am - 9:30 am
"Bridging Boundaries: A Comprehensive Look at Therapeutic Protein Biotransformation"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Intracellular Biodistribution and Biotransformation of ADC"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Replication Competent Viruses: Important Considerations for Pharmacokinetics and Biodistribution Assessment"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Non-Invasive Imaging Using the NIS Reporter Gene in Monitoring PK/PD of Virus, Gene and Cell Therapies"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DDI+: Considerations for all Ages and Stages of Drug Development and Utilization
7:30 pm - 7:55 pm
"Clinical and Drug-Drug Interaction Implications of Changes in Drug Transporter Abundance/Function in Disease"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Machine Learning Modeling of Drug DMPK Properties and DDI Predictions"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"There Is More to Pediatric DDI Than Just Ontogeny: Special Considerations for Pediatric Trial Design"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure