Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Pharmacokinetic Considerations for Non-Small Molecule Drug Modalities
Discussion Leader: Kathryn Sarullo (Washington University School of Medicine, United States)
3:45 pm - 4:05 pm
Megan Koleske (Gilead Sciences, United States)
"Simulations Driven Decision-Making for the Lead Optimization of a Solid Tumor Targeting Bispecific Antibody"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Cheng Wang (University at Buffalo, United States)
"Characterization of Antibody-Drug Conjugates Exposures in Bone Marrow-Hematopoietic Stem Cells Differentiated Neutrophil Precursors"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extra-Hepatic Drug Metabolism and IVIVE
Discussion Leader: Jiayan Le (University of Minnesota, United States)
7:30 pm - 7:40 pm
Nina Boyle (The Pennsylvania State University, United States)
"Mapping Host-Microbe Metabolism of Glucuronidated Chemicals via Mass Spectrometry"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Aurora Authement (University of Washington, United States)
"Use of In Vitro and In Vivo Studies Together with PBPK Modeling to Understand Cortisol Kidney Disposition and Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Keiann Simon (University of Washington, United States)
"THC and CBD Acyl Glucuronides are Formed by Different UGT Enzymes and Show Different Migration Rates"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Ogochukwu Amaeze (University of Washington Seattle, United States)
"Assessment of Cross-Platform Concordance of PBPK Model Performance Using Isoniazid as A Case Study"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Xinyue You (Temple University, United States)
"Propranolol Glucuronide: A Potential Substrate for CYP2C8"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Mohammed Yousuf (Temple University, United States)
"Predicting Impact of the Pgp Transporter on Drug Distribution and Disposition From Invitro Drug Transport Assays with Modeling and Simulation Approaches"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Pooja Hegde (Eli Lilly and Company, United States)
"Impact of Allosteric Modulation by Progesterone on the Prediction of Time-Dependent Inhibition of CYP3A4 Using Static and Dynamic Models"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Yifan Gong (School of Pharmacy, Temple University, United States)
"Evaluating Glycocalyx Partitioning of Basic Drugs and Developing a Novel Rat PBPK Model"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Clinical Translation and Specific Populations
Discussion Leader: Namrata Matharoo (Rutgers University, United States)
9:00 am - 9:30 am
Stephani Stancil (Children’s Mercy Kansas City, United States)
"Bedside to Bench and Back Again: A Clinical and Translational Approach to Precision Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Raeanne Geffert (University of North Carolina, United States)
"Interindividual Variability in Sulfamethoxazole Metabolism in Primary Human Hepatocytes"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Annika Tillmann (University of Manchester, United Kingdom)
"Quantification of Drug-Metabolising Enzymes and Transporters in Polycystic Kidney Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 10:45 am
Namrata Bachhav (Washington State University , United States)
"Inter-Individual Variability of Aldo-Keto Reductases (AKRs) and Hydroxy-Steroid Dehydrogenases (HSDs) in Humans and Its Potential Impact on Metabolism of their Substrates"
10:45 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Defining A Career Path In Drug Metabolism And Pharmacokinetics Research
Discussion Leader: Jessica Griffith (Novartis, United States)
1:30 pm - 2:30 pm
Panel Discussion
Defining A Career Path In Drug Metabolism And Pharmacokinetics Research
Sara Humphreys (Amgen, United States)
Patrick Glassman (Temple University, United States)
Upendra Argikar (Gates Medical Research Institute, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes