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Drug Safety (GRS)

Gordon Research Seminar

Drug Safety in the Modern Development Landscape: Innovations from Industry, Academia and Government

June 9 - 10, 2018

Chairs

and

Stonehill College

320 Washington Street

Easton, Massachusetts, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Drug Safety offers a unique, collaborative forum for graduate students, post-doctoral fellows, and early career scientists to exchange new and cutting-edge research in fields such as toxicology, precision medicine, pharmacovigilance, computational biology, and tissue engineering. The Seminar will focus on the application of novel technologies to improve drug safety evaluation throughout development. Attendees are expected to share their unpublished research in the form of a poster, and exceptional abstracts will be selected for platform presentations. In addition to extensive presentation and networking opportunities, attendees will have access to mentorship and career advice from established industry, academic, and government investigators. The Drug Safety GRS is an excellent venue to connect with peers and field leaders in a small, supportive environment prior to the Gordon Research Conference on Drug Safety, which Seminar participants are strongly encouraged to attend.

Related Meeting

This GRS will be held in conjunction with the "Drug Safety" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Advancing Microphysiological Systems Discussion Leader:
3:45 pm - 4:00 pm	"A Microphysiological Model of the Human Liver"
4:00 pm - 4:05 pm	Discussion
4:05 pm - 4:20 pm	"WAT-on-a-Chip: Microphysiological Systems Integrating White Adipose Tissue"
4:20 pm - 4:25 pm	Discussion
4:25 pm - 4:30 pm	General Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Translational Safety and Precision Medicine Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:00 pm	"Vignettes in Translational Biomarker Science"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:20 pm	"Mining Pharmacogenomic Information from Drug Labeling Using FDALabel Database for Advancing Precision Medicine"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:40 pm	"Developing Precise Immunomodulatory Therapeutics for Fetal Alcohol Spectrum Disorders"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:00 pm	"High Throughput Transcriptomics of Primary Human Hepatocyte Inter-Individual Variance in Adaptive Stress Response Activation"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:20 pm	"Inter-Individual Variability in Epigenetic and Genotoxic Responses to 1,3-Butadiene in a Population-Based Collaborative Cross Model"
9:20 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Patient-Focused Drug Safety / Mentorship Component: Career Development Panel Discussion Leader:
9:00 am - 9:20 am	"Optimization of Neuronal Differentiation Protocols with Nonlinear Model Predictive Control and Secretome-Based Moving Horizon Estimation"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	"Direct Activation of CD8+ T Cells Lays Groundwork for Mathematical Representation of Idiosyncratic Drug-Induced Liver Injury (iDILI)"
9:40 am - 9:45 am	Discussion
9:45 am - 10:00 am	"Amoxicillin-Peptide Adducts Activate T-Cells from DILI Patients in a HLA DRB115:01-DQB106:02 Risk Haplotype Restricted Manner"
10:00 am - 10:05 am	Discussion
10:05 am - 11:00 am	Panel Discussion Challenges Facing Early Career Professionals in Drug Development and Safety
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Systems Pharmacology and Toxicology Discussion Leader:
1:30 pm - 1:45 pm	"Systems Pharmacology Modeling of Intracellular Signaling in Peripheral Neurons: Identification of Dexanabinol for the Prevention of Chemotherapy-Induced Peripheral Neuropathy"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	"Computational Redesign of Organophosphate Flame Retardants and Pesticides for Improved Safety and Efficacy"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	"In Silico Trials in Human Ventricular and Purkinje Cell Models Predict Safety and Efficacy of 10 Anti-Arrhythmic Drugs"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

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