Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Endothelial Cell Heterogeneity
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
"Regulation of Arterial Endothelial Cell Specification and Artery Formation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"BMP and Blood Vessels: New Insights from Negative Regulators"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Single Cell RNAseq Analysis of Endothelial Cell Phenotypes"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Regulation of Endothelial Phenotypes
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Regulation of Endothelial Phenotype by Fluid Shear Stress"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Endothelial Cell Cycle State Determines Propensity for Arterial-Venous Fate"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Control of Endothelial Cell Identity by a GATA2-Bound Enhancer Element"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Genetic Investigation of Diverse Vascular Beds"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Microvascular Endothelial Cells in the Adaptation to Energy Transition State: DLL4 as an Adipose Depot-Specific Metabolic Hub"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Guidance of Vascular Barrier Formation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Congenital Defects and Clinical Therapy
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Genetic Basis of Primary Lymphoedema"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Mutations, Models and Targeted Treatment of Vascular Anomalies"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Target for Experimental Arthritis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"High Throughput Drug Screen Reveals a Novel Pharmacological Agent for the Treatment of Cerebral Cavernous Malformation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Vascular Therapies Targeting the TEK Pathway"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Endothelial Cell Damage, Repair and Regeneration
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Endothelial Cell Replication In Vivo"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"NRP1 Promotes Cell-Cell Adhesion for Brain Vascularization"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Temporal Adaptation of Vascular Patterning"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Hardwiring Between the Angiopoietin and VEGF Signaling Systems"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"NKX2-3 Dependent Specification of Pancreatic Endothelial Cells for Pre-Vascularized Islet Transplantation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Molecular Basis of Vascular Heterogeneity in Mediating Tissue-Specific Regulation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Aging Endothelium and Impact on Disease Progression
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"In Vivo Optical Interrogation of Neurovascular Function and Pathology"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Regulation of Cardiac Lymphangiogenesis in Cardiovascular Diseases – Impact on Myocardial Edema, Inflammation and Cardiac Function"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Overview of Actions of Tamoxifen on Endothelial Cells: Vascular Diseases and Tumor Angiogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Precision Nanomedicine Targeting Novel Endothelial Mechano-Sensing Mechanisms"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hematovascular Interactions in Development and Disease
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"New Insights into the Regulation of the Endothelial to Hematopoietic Transition"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"RUNX1 is Required for the Development of Pulmonary Arterial Hypertension"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cis-Regulatory Architecture of Coronary Vascular Cells During Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Vessel Type-Specific Mechanisms of Lymphatic Development and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Comparing Roles for KIT in Vascular and Hematopoietic Development"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Clonal Hematopoiesis: Acquired Mutations in Hematopoietic Stem Cells that Contribute to Vascular Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Vascular Imaging and Bioengineering
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Imaging Lymph Vessel Development and Heterogeneity"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Ratiometric Multispectral Mosaics Reveal Exclusionary Zoning During Angiogenesis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Spatial Organization of Lymphatic Vessels and Adipocyte Microenvironment"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Live Imaging of Mechanosensitive Signals in the Developing Endocardium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Circulating Bioactive Lipid Chaperones in Endothelial Cell Resilience"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Metabolic-Control of Translation During Angiogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Angiocrine Metabolic Signaling Regulates Adiposity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Vascular Metabolism: Role and Regulation During Quiescence and Growth"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Sex-Related Pathophysiological Differences in Endothelial Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Pericyte Loss and Active Vessel Regression Drive Early Events in Diastolic Heart Failure"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Metabolic Control of Cell Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Approaches to Understanding Cellular Diversity
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Principles and Regulation of Vascular Remodeling – the Junction in Focus"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"High-Throughput Proteo-Genomic Identification of Endothelial Microproteins Encoded by Non-Canonical Small Open Reading Frames"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Identification of Molecular Targets to Modulate Endothelial Senescence"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Understanding the Multiple Functions of Endothelial Caveolae at Blood-Neural Barriers"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure