Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Multifaceted Roles of Unique Cofactors in Catalysis and Beyond
Discussion Leader: Callum Nicoll (University of Pavia, Italy)
3:45 pm - 4:15 pm
Jennifer Bridwell-Rabb (University of Michigan, United States)
"A Rieske Route for Site-Specific Functionalization"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fundamentals of Mechanistic Enzymology
Discussion Leader: Antonio Del Rio Flores (Stanford University, United States)
7:30 pm - 7:45 pm
Marta Massari (University of Pavia, Italy)
"Unlocking Thermostability and Enzymatic Studies of IL4i1 through Ancestral Sequence Reconstruction: Structural Insights and Inhibitor Development"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Lucas Calzini (University of Delaware, United States)
"Differential Regulation of Fe(II)/2-Ketoglutarate-Dependent Dioxygenase Family RNA Demethylases by Cofactor Ascorbate"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Dann Rivera (University of Texas at Austin, United States)
"Discovery and Optimization of a Lysine-targeted Covalent Inactivator of NDM-1"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Noah Lyons (Virginia Tech, United States)
"Functional and Mechanistic Characterization of a Plant Flavin-Dependent S-Monooxygenase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Sabina Maurer (University of Pennsylvania, United States)
"Cryptic Sulfotransferases for Aziridine Formation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jessica Kugblenu (Georgia State University, United States)
"The Role of Histidine 421 Residue in the Catalytic Mechanism of Pseudomonas aeruginosa D-2-Hydroxyglutarate Dehydrogenase"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Methods in Computational and Experimental Enzymology
Discussion Leader: Michael Rankin (University of Michigan, United States)
9:00 am - 9:15 am
Duncan Muir (UCSF, United States)
"High-Throughput Dissection of the Evolutionary Landscape of Enzyme Catalysis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Shravan Dommaraju (University of Illinois at Urbana-Champaign, United States)
"Algorithm Development for the Discovery of New Biosynthetic Reactions"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Mikaela Farrugia (University of Notre Dame, United States)
"Synergistic Approaches to Elucidation of Enzyme Mechanisms/Dynamics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Suman Samantray (Pacific Northwest National Laboratory, United States)
"The Hidden Chokepoints: Exploring Gas Diffusion in the CODH/ACS Enzyme Complex using Molecular Simulations"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tom Smisek (University of Texas at Austin, United States)
"Use of Synthetic Nanodiscs for Purification of New Delhi Metallo-ß-Lactamase, a Lipidated Antimicrobial Resistance Enzyme"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Alejandro Garcia (University of Michigan, United States)
"Mind the Gap: Clarifying the Role of Bridging Residues for Electron Transfer in Rieske Oxygenases"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Strategies for a Successful Career in STEM
Discussion Leader: Melanie Johnston (Rutgers University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Strategies for a Successful Career in STEM
Randy Kipp (Relay Therapeutics, United States)
Anne-Frances Miller (University of Kentucky, United States)
Andrea Mattevi (University of Pavia, Italy)
Anirban Banerjee (National Institutes of Health, United States)
Y. Jessie Zhang (University of Texas, Austin, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes