Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Complexities of Epigenetic Mechanisms
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Quantifying the Landscape and Dynamics of the Acetylome"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"A New Mode of Xist Action"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contribution of the Epigenome to Cardiac Development and Regeneration
9:00 am - 9:20 am
"Molecular Drivers of Cardiomyocyte Maturation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Hippo Signaling in Epigenetic Regulation of Heart Development and Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
"A Lamin A/C Mutation Responsible for a Cardiomyopathy Impairs Epigenetic Regulation of Heart Development: Rescue of the Mouse Phenotype by a Chromatin Modifier Inhibitor"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Single-Cell Genomics Analysis of Postnatal Heart Development and Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Epigenetic Regulation of Cardiomyocyte Differentiation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TET Inactivation Perturbs Long-Range Chromatin Interactions During Cardiac Development "
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Transcriptional and Epigenetic Networks in Cardiovascular Lineage Commitment and Differentiation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Methylation and Editing in Cardiovascular Disease
7:30 pm - 7:50 pm
"RNA Methylation in the Regulation of Cardiac Hypertrophy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"FTO-Regulated Cardiac Epitranscriptome in Disease and Therapeutics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"RNA Methylation in Endothelial Cell Biology and Function"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"TAZ: A New Player in the Epigenetic Regulation of Cardiomyocyte Hypertrophy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"RNA Modifications in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Impact of Mitochondria, Fat and Sex on the Epigenome in the Heart
9:00 am - 9:20 am
"Regulation of Histone Deacetylase 4 by Lipid Droplet Associated Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sex Based RNA Methylation in the Heart"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Hypermethylation of Mitochondrial DNA in Vascular Smooth Muscle Cells Impairs Arterial Contraction"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Protein Arginine Methyltransferases Regulate Cardiac Function and Energy Metabolism"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Recruitment of Metabolic Enzymes to Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeting Transcription in Heart Failure"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mitochondria, Metabolism and Epigenetics in Cellular Reprogramming"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
The Role of Epigenetics in the Pathogenesis of Vascular Disease
4:00 pm - 4:20 pm
"Uncovering New Mechanisms of Vascular Disease in the Non-Coding Genome"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:50 pm
"The Role of RNA Modification in Vascular Regeneration"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
"Mechanical Stress, Endothelial Inflammation and Atherogenesis"
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
"Regulation of Angiogenesis by lncRNAs"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Remodeling and Architecture in Cardiovascular Disease
9:00 am - 9:20 am
"Understanding How Genome Organization Instructs Cardiac Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Hypertrophic Growth by the Smyd Family of Histone Methyltransferases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Chromatin Compartment Dynamics in a Halploinsufficient Model of Cardiac Laminopathy"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Integrating Structure and Accessibility in Models of Cardiac Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Transcriptomic and Epigenetic Profiling Reveal a Ground State of Cardiomyocyte Crucial for Heart Maturation and Regeneration"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identification and Functional Epigenetic Modulation of Chromatin Interactions in Cardiac Myocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Targeting Nucleosomes and Enhancer RNAs for Direct Fibroblast Reprogramming and Anti-Fibrotic Therapy
7:30 pm - 7:50 pm
"Molecular Barriers to Direct Cardiac Reprogramming"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Regulation of Cardiac Gene Reprogramming in Response to Cell Signaling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Targeting Enhancer-Signaling in Cardiac Fibrosis and Heart Failure Pathogenesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"The Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Therapy for Heart Disease via Targeting Enhancer-Associated Long Noncoding RNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional Control of Cardiovascular Disease
9:00 am - 9:20 am
"New Cardiac Specific Non-Coding RNAs Regulating Cardiac Transcription Factors and Epigenetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Dynamics of the Epigenome in Cardiac Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"In Vivo Function of Flow-Responsive cis-DNA Elements in the Endothelial Nitric Oxide Synthase Gene: A Role for Chromatin-Based Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Molecular Mechanisms of Heart Failure Dissected by Single Cell RNA Seq Analysis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Acetyl-CoA Production by Specific Metabolites Promotes Heart Repair After Myocardial Infarction via Mediating Histone Acetylation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Using Epigenetics to Identify Genetic Determinants of Heart Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dnmt3a: An Epigenetic Regulator During Postnatal Angiogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Glucose-Sensitive Cadiokine/Myokine MG53 Impairs Multiorgan Insulin Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Epigenetic Therapies for Cardiovascular Disease
4:00 pm - 4:20 pm
"Reversible Protein Acetylation and Disease-Related Myocardial Remodeling "
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:40 pm
"Epigenetic Profiling of Cardiac Pacemaker Cells: Insights into the Origin and Regulation of Heart Rhythm"
4:40 pm - 4:45 pm
Discussion
4:45 pm - 5:05 pm
"Targeting Jumonji C Histone Lysine Demethylases in Pathological Cardiac Remodeling"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
"Multiomics Dissection of Heart Failure for the Development of Cardiovascular Precision Medicine"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
"Epigenetic Modifying Therapy for Cardiovascular Disease that Targets BET Proteins"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
