Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Single Cell Resolution of Cardiac Epigenetic Landscape
7:40 pm - 8:20 pm
"Single-cell Epigenomics in Health and Disease"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"RNA-DNA-DNA-Triplex Formation as a Mechanism Controlling Endothelial Gene Expression by lncRNAs"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"CTCF as a Therapeutic Target for Structural Repair of the Failing Heart"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epigenetics in Development and Congenital Heart Diseases
9:00 am - 9:20 am
"Understanding Nkx2-5-Associated Congenital and Adult Heart Disease"
9:20 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:45 am
"DNA Damage Response in Hereditary Cardiomyopathies"
10:45 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Epigenetic Landscape Reveals Endothelial Cell Identity Regulator in Cardiovascular Development and Diseases"
11:20 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Sex-Specific Remodeling Of The Cardiac Transcriptome And Chromatin Landscape During Human Development"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Genome-Wide CRISPR screen Identifies an NF2-adherens Junction Mechanistic Dependency for Cardiomyocyte Lineage Specification"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Landscape in CV System
7:30 pm - 7:50 pm
"Novel Insights From Mammals of Extreme Longevity into Genetic and Epigenetic Regulation of Heart Regeneration and Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Wonderland of Epigenetic Reprogramming"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Using Genomic Data to Predict Disease Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Defining Cardiac Functional Recovery in End-Stage Heart failure at Single Cell Resolution"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Players and Mechanisms in CV Epigenetic Regulatory Network
9:00 am - 9:20 am
"Characterizing Novel BRD4-Dependent Nuclear Proteins In The Heart"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Non-Coding RNAs Mediated Regulation Of Lipid Metabolism And Vascular Health"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Epigenetic Control in Clonal Hematopoiesis and Impact on Heart Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Regulation of Cardiac Rhythm and Arrhythmias"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Transcriptional Regulation Of Pacemaker Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"3D Chromatin Architectures and Transcription Regulation in Diabetic Endothelial Dysfunction"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Control of Endothelial Cell Function and Arteriogenesis by MEG3:EZH2 Epigenetic Regulation of Integrin Expression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Epigenetics
7:30 pm - 7:50 pm
"The Crosstalk Between Metabolism And Epigenetics Determines Cardiomyocyte Fate"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Interplay Between Epigenetics And Metabolism In Cardio-Oncology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Epigenetic Regulation Of Hidden Cardiac Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Friendly YAP in Compensatory Cardiac Hypertrophy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Histone Methyltransferase SETD2 Drives Cardiometabolic Heart Failure with Preserved Ejection Fraction"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics in Cardiovascular Precision Medicine
9:00 am - 9:20 am
"Epigenomic dysregulation of retrotransposons in human diseases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Regulation Of Vascular Smooth Muscle Cell Plasticity, One Cell At A Time"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Methylation And Mortality In Patients With Aortic Stenosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Mechanism in HFpEF Pathogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Epigenetics in Dilated Cardiomyopathy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identification of Causal Non-Coding Genetic Variants of Cardiac Function"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Dynamic RNA Binding Protein Cpeb4 Regulates Cardiomyocyte Growth and Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Regulation Beyond Chromatin
7:30 pm - 7:50 pm
"mRNA Metabolism And Translational Control In Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"mRNA Stability and Regulation in CV Function and Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Myocardial Lipid Accumulation Causes Cardiac Inflammation and Dysfunction Through Nr4a1 in a Sex-Dependent Manner"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Sexually Dimorphic Heart Phenotypes in Mice Lacking Chromatin Factors in Cardiomyocytes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"MPTM1: A Cardiac and Slow Muscle Fiber Enriched Microprotein Essential for Normal Muscle Physiology"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Industry Collaboration and Commercialization in Epigenomic Medicine"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Epigenetic Regulation of Cardiomyocyte Reprogramming
9:00 am - 9:20 am
"Dissecting Gene Regulation In The Human Heart Using Single-Cell Multi-Omic"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenetic Regulation Of Cardiomyocyte Proliferation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"A Cardiac Transcriptional Enhancer is Repurposed During Regeneration to Activate an Anti-proliferative Program"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cardiomyocyte Maturation And Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Non-coding RNA in Cardiomyocyte Maturation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Gridlock/Hey2 Transcriptional Repressor Impedes Vertebrate Heart Regeneration by Restricting Expression of Lysine Methyltransferase"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"HDAC11 Regulates Gene Expression through Reversible Signal-Dependent Histone Myristoylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Insights into Heart Development, Disease and Regeneration
7:30 pm - 8:15 pm
"New Insights into Heart Development, Disease and Regeneration"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Epigenetic Control of Inflammation by Histone Methylation in Cardiometabolic Heart Failure with Preserved Ejection Fraction"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Ezh2 as an Epigenetic Checkpoint Regulator During Monocyte Differentiation: a Potential Target to Improve Cardiac Repair after Myocardial Infarction"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure