Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
"3D Folding and Enhancer Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Two Mechanisms of Nuclear Organization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Condensate Model for Gene Activity and Genome Organization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription, Epigenetic Regulation and Genome Organization at Single Genes in Live Cells"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transposable Elements and Epigenome Evolution
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Avoiding Replication and Transcriptional Collisions by Repressing Repeats and Forming Nuclear Foci"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"How TEs and Their Krab-ZFP Controllers Shape Human-Specific Transcription Networks"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"pUG-Tailed RNAs Drive Gene Silencing and Transgenerational Epigenetic Inheritance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Functional Evaluation of Transposable Elements as Enhancers in Mouse and Human Trophoblast"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Control of Non-Coding RNA Production and Histone Levels by a 5'tRNA Fragment"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Using Metatherians to Elucidate the Evolution of Mammalian Epigenetic Pathways"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA-Mediated Epi-Regulation
7:30 pm - 7:50 pm
"Small RNAs and Dosage Interactions in Plants"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Gene Regulation in Arabidopsis "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sexually Dimorphic Expression of piRNAs in C. elegans "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Paternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance via Sperm Small RNAs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Programming Future Generations
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Remembering the Past: A New Form of Protein-Based Epigenetics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Principles of Developmental Reprogramming and Gametogenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Heterochromatin Establishment by the Chromatin Remodeling Factor DDM1 in Arabidopsis "
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Principles of Nucleosome Phasing Revealed by Genome-Wide Mapping and In Vitro Reconstitution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The C. elegans MES Chromatin Regulators Ensure Germline Survival by Repressing the X Chromosomes"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"SPR-5; MET-2 Maternal Reprogramming Antagonizes H3K36me3 in the Control of Germline Versus Soma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reprogramming During Development
7:30 pm - 7:50 pm
"Programmed DNA Elimination: Silencing Germline-Expressed Genes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Inheritance and Reprogramming in Early Mammalian Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Establishment and Maintenance of Specialized Chromatin Domains"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Distinct Architectures of Germ Line and Somatically Expressed Genes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Memory and Maintenance
9:00 am - 9:20 am
"Epigenetic Control of Programmed Genome Rearrangements in Paramecium "
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Domestication of Transposable Elements for Plant Reproduction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Control of Convergently Transcribed Genes Through Modulating Gene-Body Chromatin Modifications"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Super-Enhancer Switching Drives a Burst in Germline Gene Expression at the Mitosis-to-Meiosis Transition"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Biased Fork Movement Coupled with Strand-Specific Histone Incorporation Ensures Asymmetric Histone Inheritance"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Epigenetic Inheritance Independent of Asymmetric Histone Inheritance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Regulation of Differentiation by Novel Chromatin Remodelers and Promoters"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Biophysics and Mathematical Models
7:30 pm - 7:50 pm
"Polymer Physics Predicts the Impact of Structural Variants on Chromatin 3D Architecture"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Modeling Polycomb-Mediated Epigenetic Silencing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Kinetics of DNA Maintenance Methylation at Single Molecule Level and Underlying Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"3D Chromatin Organization and Gene Regulation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Antisense-Mediated Chromatin Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenetic Regulation of Sex Determination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cellular Heterogeneity in Circadian Oscillation Driven by DNA Methylation and Transcriptional Noise"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A Role for Epigenetic Reprogramming During Meiosis in Plants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"H3.3K27M-Induced Chromatin Changes Drive Ectopic Replication Through Misregulation of the JNK Pathway"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Phosphorylation of Histone H3.3 at Serine 31 Promotes p300 Activity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Function and Disease
7:30 pm - 7:50 pm
"Unexpected Contributors to the Establishment of X Inactivation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"(Epi)genetic Control of Phenotypic Variation and Disease Heterogeneity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mechanisms of Transgenerational Epigenetic Inheritance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Key Role for HUSH in Triplet-Repeat Silencing in Disease?"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure