Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Elucidating Extracellular Vesicle Modulation of Disease and Clinical Potential
Discussion Leader: Jaehyoun Seiler (Stowers Institute for Medical Resesarch, United States)
3:45 pm - 3:55 pm
Nina Erwin (University of Florida, United States)
"Delivery of Proteolysis Targeting Chimeras Through Extracellular Vesicles for Treating Triple Negative Breast Cancer"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
James Coy-Dibley (Northwestern University, United States)
"The Role of Keratinocyte-Derived Exosomes on DRG Excitability and Neurite Outgrowth in Painful Diabetic Neuropathy"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Ajay Shankaran (University of Michigan, United States)
"Non-Small Cell Lung Cancer Cells Leverage Extracellular Vesicles to Induce Alterations in Neutrophil Function and Metabolism to Promote Immunosuppression"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Deciphering Extracellular Vesicle Biogenesis and Functionality
Discussion Leader: Kate Williams (Colorado State University, United States)
7:30 pm - 7:45 pm
Martina Fabiano (Johns Hopkins University, United States)
"Plasma Extracellular Vesicles Dampen Neutrophil Inflammatory Responses and Allow Macrophage Imprinting with an Anti-Inflammatory Signature"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Audrie Langlais (MaineHealth Institute for Research, United States)
"Morphine Limits Neural-Bone Crosstalk via Suppression of Extracellular Vesicles"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Maria Laura Tognoli (University Medical Centre Utrecht, The Netherlands)
"uPA and Serpin E2 on the Extracellular Vesicle Surface Mediate Vesicle Internalization"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
PRERAK GUPTA (University of Illinois at Chicago, United States)
"Tailoring Extracellular Vesicles with Notch Ligands to Treat Vascular Injuries"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Samantha Ali (University of Florida, United States)
"Exploring Extracellular Vesicles in Skeletal Muscle Under Varying Conditions for Therapeutic Nanomedicine in Space"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Luke Nelson (University of Hawaii, United States)
"Rab GTPases Cooperate with the Exocyst Complex to Release Skeletal Muscle EVs upon Contraction Signaling"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Methods to Develop Extracellular Vesicle Rigor and Analysis
Discussion Leader: Filipa Dias Louro (AstraZeneca, Sweden)
9:00 am - 9:35 am
Koen Breyne (Massachusetts General Hospital and Harvard Medical School, United States)
"Enrichment of Extracellular Vesicles and Viral-Like Particles by Tetraspanin Engineering and Immuno-Capture to Improve Payload Delivery"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Sara Veiga (Massachusetts General Hospital/ Harvard Medical School, United States)
"Cell Culture Mechanics are Important for EV Generation and Cargo Loading"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sara Whiteman (Harvard University, United States)
"Pipeline for Novel Neuron Extracellular Vesicle Marker Discovery and Measurement of Internal Cargo Proteins"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Gwen O'Driscoll (The Institute of Cancer Research, United Kingdom)
"Engineering MRI-Detectable EVs to Study Breast Cancer Metastasis Organotropism in vivo "
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Raheel Ahmad (Massachusetts General Hospital and Harvard Medical School, United States)
"pH-Responsive Biomaterials for the Isolation of Extracellular Vesicles from Biofluids"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Gabriel Arias (University of North Carolina at Chapel Hill, United States)
"Ultra-Pure Isolation of Extracellular Vesicles and Viruses at Scale"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
The Impact of Extracellular Vesicles from Non-Model Systems
Discussion Leader: Jeff Bouffard (Concordia University, Canada)
1:30 pm - 1:55 pm
Irma Schabussova (Medical University of Vienna, Austria)
"From Bacteria with Love: Extracellular Vesicles as Mediators of Bacterial and Immune System Communication"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:25 pm
Curtis Logan (Concordia University, Canada)
"Characterizing Probiotic Yeast Extracellular Vesicles"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes