Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Elucidating Extracellular Vesicle Modulation of Disease and Clinical Potential
3:45 pm - 3:55 pm
"Delivery of Proteolysis Targeting Chimeras Through Extracellular Vesicles for Treating Triple Negative Breast Cancer"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
"The Role of Keratinocyte-Derived Exosomes in Painful Diabetic Neuropathy"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"Investigating the role of Non-Small Cell Lung Cancer Extracellular Vesicles in Altering Neutrophil Function and Metabolism"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Deciphering Extracellular Vesicle Biogenesis and Functionality
7:30 pm - 7:45 pm
"Plasma Extracellular Vesicles Dampen Neutrophil Inflammatory Responses and Allow Macrophage Imprinting with an Anti-Inflammatory Signature"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Morphine Limits Neural-Bone Crosstalk via Suppression of Extracellular Vesicles"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Identifying Molecular Drivers of Extracellular Vesicle-Mediated RNA Transfer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Tailoring Extracellular Vesicles with Notch Ligands to Treat Vascular Injuries"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Exploring Extracellular Vesicles in Skeletal Muscle Under Varying Conditions for Therapeutic Nanomedicine in Space"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Rab GTPases Cooperate with the Exocyst Complex to Release Skeletal Muscle Extracellular Vesicles upon Ca2+ Flux"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Methods to Develop Extracellular Vesicle Rigor and Analysis
9:00 am - 9:35 am
"Enrichment of Extracellular Vesicles and Viral-Like Particles by Tetraspanin Engineering and Immuno-Capture to Improve Payload Delivery"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Cell Culture Mechanics are Important for EV Generation and Cargo Loading"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Pipeline for Novel Neuron Extracellular Vesicle Marker Discovery and Measurement of Internal Cargo Proteins"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Engineering MRI-Detectable EVs to Study Breast Cancer Metastasis Organotropism in vivo "
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"pH-Responsive Biomaterials for the Isolation of Extracellular Vesicles from Biofluids"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Isolation of EVs and Viruses Using Microfluidic TFF-Based Methods"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
The Impact of Extracellular Vesicles from Non-Model Systems
1:30 pm - 1:45 pm
"From Bacteria with Love: Extracellular Vesicles as Mediators of Bacterial and Immune System Communication"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"Characterizing Probiotic Yeast Extracellular Vesicles"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Follow the Fate of Tumor Derived EVs"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes