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Fertilization and Activation of Development (GRS)

Gordon Research Seminar

The Basics of Gamete Biology and Early Development and Their Clinical Implications

July 22 - 23, 2023

Chairs

and

Holderness School

33 Chapel Lane

Holderness, New Hampshire, United States

Venue and Travel Information

Conference Description

The Fertilization and Activation of Development GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

This meeting will bring together researchers who use diverse model organisms to understand the complexity of gametogenesis, fertilization and early embryo development. In addition, we will showcase basic research and methods that can be translated into new approaches to support the evolution of Assisted Reproductive Technologies, the contraceptive research field and other clinical applications.

Due to limited accommodations at this venue, guest housing is very limited. To request family/guest housing please reach out to your Conference Operations Associate.

Related Meeting

This GRS will be held in conjunction with the "Fertilization and Activation of Development" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Molecular Changes in Eggs, Sperm, and Females that Mediate Fertility Discussion Leader:
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:20 pm	"Molecular changes in eggs, sperm, and females that mediate fertility"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Approaches in Fertilization Research Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Intramitochondrial Calcium Increase: A Conserved Mechanism of Mitochondrial Activation in Human and Mouse Sperm During Capacitation"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Unlocking the secrets of calcium oscillations at fertilization"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"High-Resolution structures of sperm flagella"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Revealing the secrets of ovulation"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:10 pm	"Anaphase B Spindle Elongation and Integrity in C.elegans Female Meiosis"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Targeting CatSper Extracellular Domains using Antibodies as Contraceptive Agents to Prevent Fertilization"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Gamete Production and Function Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:20 am	"Molecular Basis for Maternal Inheritance of Human Mitochondrial DNA"
9:20 am - 9:25 am	Discussion
9:25 am - 9:40 am	"Mitochondrial dynamics drive meiosis and contribute to the development of high quality human oocytes"
9:40 am - 9:45 am	Discussion
9:45 am - 10:00 am	"Testis-specific F-box protein FBXTS1 plays an important role in mouse spermiogenesis"
10:00 am - 10:05 am	Discussion
10:05 am - 10:20 am	"The helical structure of polymerized actin in the mouse sperm flagellum undergoes a structural change to cease motility at the time of sperm-egg fusion"
10:20 am - 10:25 am	Discussion
10:25 am - 10:40 am	"PLCD4 is the sperm factor required for Ca²⁺ oscillations in PLCZ-null mice."
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Exploring Gamete (In)compatibility as a Cause of Subfertility"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Hints to Boost your Career (Career Panel) Discussion Leader:
1:30 pm - 1:40 pm	"Scientific Careers in Government"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 1:55 pm	"Careers in Scientific Editing and Research Development"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:10 pm	"NICHD Extramural Research Programs, Priorities, and Funding Opportunities"
2:10 pm - 2:15 pm	Discussion
2:15 pm - 2:25 pm	"Coming Full Circle: Nonlinear Career Path Opportunities"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R13HD105414. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Fertilization and Activation of Development

July 27 - August 1, 2025

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