Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Early Development, Organogenesis and Evolution
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"FGF Signaling in Inner Ear Development and Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Genetic Robustness in Signaling Pathways"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"A Novel FGF9 Variant Reveals a Role for Dimerization in Sex Determination"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Musculoskeletal and Craniofacial Roles
9:00 am - 9:20 am
"FGF Signaling in Skeletal Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Mechanisms of Craniosynostosis in Bent Bone Dysplasia Syndrome"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Activating FGFR3 Mutant Causes Hypochondroplasia with Fragile Bones Showing a Novel Pathological Defect in Cortical Bone in Mice"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Fibroblast Growth Factor Receptor 1 and 2 is Essential for Development and Differentiation in Salivary Glands"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Role of FGFR in Heart and Skeletal Muscle Morphogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Role of Fibroblast Growth Factor Receptor 4 in Physiologic Cardiac Hypertrophy"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Fgfs And Integration of The Developing Ear: Coordinating Development To Make An Ear Drum"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Skeletal Muscle is a Novel Source of FGF23 in Mouse Models of Chronic Kidney Disease and Skeletal Muscle Atrophy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interaction of FGFs with Other Signaling Pathways
6:00 pm - 6:20 pm
"Enhancer Regulation by FGF/ERK in Pluripotent Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Understanding Syndromic Microtia: FGFs in the Interphase Between Muscle and Cartilage"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Receptor Tyrosine Kinase-Interactomes, Drug Actions and Genome-Informed Medicine"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"FGF Signalling in Cranial Joint Development"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Reciprocal Interactions Mediated by FGF and Wnt Signaling Coordinate the Growth of the Optic Cup and Lens"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stem Cells, Tissue Regeneration and Repair
9:00 am - 9:20 am
"FGF Signaling in Lung Development and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"FGF Signaling in Epithelial Injury and Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Fgf Signaling in the Mesenchymal Niche of the Hair Follicle Regulates Stem Cell Quiescence and Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Role of FGFR2b Signaling in Alveolar Epithelial Cells During Homeostasis, Regeneration and Repair"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Role of FGF10 in an Evolutionary Conserved Population of Ionocytes"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Niche-Mediated Repair of Airways via Fgf10 is Directed in a Position Dependent Manner"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural Biology of FGFs and Novel Technologies
6:00 pm - 6:20 pm
"FGFR Functional Selectivity in Breast Cancer Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Novel Genetic Tools To Probe Enhancer Regulation By Fgf/Erk In Pluripotent Stem Cells"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"An Asymmetric FGF Receptor Tyrosine Kinase Dimer Mediates A-loop Tyrosine Trans-Phosphorylation and Signaling"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"The Synergistic Roles Of Klothos in Increased Longevity and Healthy Lifespan in the Nematode C. elegans"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
FGFs in Cancer: Mechanism, Progression and Therapy
9:00 am - 9:20 am
"Therapeutic Targeting of FGFR Signaling in Pancreatic Adenocarcinoma"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"A Multi-Omics Approach to Understand FGFR2b and EGFR Functional Crosstalk and RSK2-Dependent Signalling in Breast Cancer Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"FGF Signaling in Cancer Cell Metabolism"
10:05 am - 10:15 am
Discussion
10:25 am - 10:35 am
"Role(s) Of FGFR3 During Axial Skeleton In Two Fgfr3 Mouse Models"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Functions of FGF Receptor Signaling on Cancer Stem Cells in Glioblastoma"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"FGF9 Induces Angiogenesis Mediated by Mesenchymal Cell FGFR1/3 Dependent Mechanisms"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
"Protective Role of Smooth Muscle FGF Signaling in Hypoxia-Induced Pulmonary Hypertension"
12:30 pm - 12:40 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Metabolic Homeostasis and Endocrine Functions
6:00 pm - 6:20 pm
"Targeting the Brain to Treat Diabetes: Lessons and Insights from Fibroblast Growth Factor 1 (FGF1)"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Endoplasmic Reticulum (ER) Stress Disrupts FGF Siignaling Via Altered Processing of FGF Receptors"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Regulation of Selective Autophagy by FGF Signaling"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Decreased FGF Signaling in Human Reproduction"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-Driven Regulation of Autophagy and Survival"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
FGFs in Development and Disease of the Nervous System
9:00 am - 9:20 am
"Abelson Kinases Regulate FGF Signaling in Lens Vesicle Closure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"FGF18 is Involved in Postnatal Ventricular-Subventricular Zone (V-SVZ) Neurogenesis"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"FGF Signaling in Myelination and Multiple Sclerosis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"FGF Signaling Potentiates Müller Glia for Retinal Regeneration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"FGF3 Promotes the Development of Hindbrain Boundaries as NPSCs via Interacting With Their ECM"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Characterising the FGF Signaling Pathway in the Postnatal Pituitary Stem Cell Compartment"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"FGF Triggers Cytoskeletal Remodelling During the Morphogenesis of the Cochlea"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intracellular-Acting and Non-Canonical FGFs
6:00 pm - 6:20 pm
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Evaluation of the Therapeutic Potential of FGF-2HMW and FGF-2LMW in an In Vitro Model of Parkinson’s Disease"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Investigating Non-Canonical FGFs Using Proximity-Labeling Proteomics"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"FGF Homologous Factors are Secreted Proteins That Induce Signaling in Cells Expressing FGF Receptors"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Protein-Protein Interactions of FGF12 - An Indication of a Novel Intracellular Function"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure