Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Extracellular Matrix in Tissue Function
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
"Evolutionary Dawn of the Extracellular Matrix and Epithelial Tissues"
8:40 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
How Signals from the Matrix Control Cell Fate
9:00 am - 9:20 am
"Matrix Control of Liver Fibrosis"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Mechanical Regulation of Fibroblast Pro-Fibrotic Phenotypes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"ECM-Dependent Circadian Clocks"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Impaired Adhesion to the Stem Cell Niche ECM Affects the Regenerative Capacity of Aged Skeletal Muscle"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Therapeutic Targeting of Integrins In Vivo "
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Matrix Architecture and Cell Function
7:30 pm - 7:50 pm
"Matrix Architecture in Ageing"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Nanoclusters Are Building Blocks of Cell-Matrix Adhesions"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Unveiling Adhesion Regulation Mechanisms Using Engineered Microenvironments"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Sterile Inflammation Enhances EMC Degradation in Integrin β1 KO Embryonic Skin"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Mechanotransduction in Collective Cell Migration"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Integrin/Src-Mediated YAP/TAZ Activation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of EMT and Tumour Metastasis by Matrix Stiffness"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Mechanisms of Cancer Metastasis"
11:30 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Interaction Between Integrin a6b4 and BPAG1e"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Novel Complex Regulating Integrin Sorting to Recycling Endosomes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Extracellular Matrix and Stem Cells
7:30 pm - 7:50 pm
"The Matrix in Neuronal Stem Cells and Fate"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"BM Laminins Regulate Stemness by Guiding Asymmetric Cell Division"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Engineering Synthetic ECMs for Stem Cells"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Novel Metastasis Modulators Involving Stromal ECM"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Inhibiting Integrin α5β1 Modulates Matrix Formation in the Tumor"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"ECM Remodelling During Cancer Progression and Metastasis"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Integrins as Cancer Therapeutic Targets"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Immunology of ECM-Derived Biomaterials in Regeneration and Cancer"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Talin Regulates Discoidin Domain Receptor1-Mediated Cell Junctions"
7:50 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Myosin-X Filopodia and Cancer Cell Invasion"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Migration in Fibrous Microenvironments"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"ARF1-Induced Myosin II Suppresion of Podosomes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Endocytic Uptake and Retrograde Trafficking of Focal Adhesion Proteins"
9:20 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Co-Trafficking of Beta 1-Integrin and c-Met Promote Cancer Cell Survival"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Analyzing Integrin Trafficking and Its Role for Integrin Function and Stability"
10:20 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Exosomes and Metastasis"
11:30 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Integrins and Trafficking"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: How the Adhesome Works
7:30 pm - 7:40 pm
"Talin as a Mechanosensitive Signaling Platform"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
"Unraveling Integrin Sorting in Epithelial Cells by Synchronizing Integrin Trafficking"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:50 pm
"Deconvoluting the Adhesome"
8:50 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure