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Food Allergy

Gordon Research Conference

Immune Mechanisms and Targeted Therapies in Food Allergy

January 7 - 12, 2024

Chairs

and

Vice Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The Food Allergy GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 Food Allergy Gordon Conference aims to bring together the global community of basic science and clinical investigators, invested organizations, and stakeholders to discuss recent advances in our understanding of immune mechanisms involved in the induction of tolerance versus allergic responses to food and the application of these principles to emerging treatment approaches for food allergy. Novel areas of concentration include key systems that interact with and shape immunity, including microbiome, epithelial interfaces, the nervous system, and the neuroendocrine system. We will also highlight science supporting emerging treatment approaches for food allergy.

This 2024 Food Allergy GRC aims to stimulate discussion among investigators from multiple disciplines and disease areas, to place food allergy research in the larger context, and ideally advance collaborative science and new discoveries.

Related Meeting

This GRC will be held in conjunction with the "Food Allergy" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Food Allergy and Type 2 Immunity Discussion Leader:
7:40 pm - 8:25 pm	"The History of Food Allergy"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	"Regulation of Allergic Inflammation"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Food Allergy Genetics and Epidemiology Discussion Leader:
9:00 am - 9:20 am	"Food Allergy Genetics: A Perspective on Identifying Risk and Tailoring Therapy"
9:20 am - 9:25 am	Discussion
9:25 am - 9:45 am	"The Public Health Impact of Food Allergy: Prevalence, Severity, Disparities, and Access"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Fatal Anaphylaxis: Bad Luck or Something We Can Predict?"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Biological Mechanisms Impacting Health Disparities in Allergic Disease"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Atopic Disease in Inborn Errors of Immunity"
11:30 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Genetic Disorders and Traits in Severe Allergic Inflammatory Responses"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Peanut Sensitization is Common in School-Aged Children from Honduras: Relevance of CCDs but Not Major Peanut Component Allergens"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Leveraging the Genetics of Mixed Ancestry in Food Allergy"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms of Type 2 Immunity Discussion Leader:
7:30 pm - 7:50 pm	"Allergen-Specific Inhibitors of Systemic Anaphylaxis"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"iNKT Cell Stimulation Leads to the Production of Gut Peanut-Specific Immunoglobulin A Through a Type 2 Conventional Dendritic Cell-Dependent Pathway"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Pathophysiology of FPIES"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"IgE Produced in Food Allergy is Dependent Upon IL-4 Derived from T Follicular Regulatory Cells"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Innate Immune Mechanisms Regulating Type-2 Immunity"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Early Introduction and Tolerance Discussion Leader:
9:00 am - 9:20 am	"The Role of Detergent in Eosinophilic Esophagitis"
9:20 am - 9:25 am	Discussion
9:25 am - 9:45 am	"Keeping Up with the Neighbors: Understanding Local Control of Epidermal Stem Cell Behaviors with Intravital Imaging"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Can Tolerance be Restored Through Early Treatment of Allergic Infants and Toddlers?"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Are There Long-Term Consequences of Asymptomatic Food Sensitization?"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Loss-of-Function Variants in Transforming Growth Factor Beta (TGFb) and Allergic Disease"
11:30 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Targeting the Skin for Allergy Prevention"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Neutralizing IgG4 Antibodies are a Biomarker of Sustained Efficacy After Peanut Oral Immunotherapy"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Susceptibility to Oral Anaphylaxis is a Heritable Trait in Mice"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms of Sensitization, Skin and Gut Discussion Leader:
7:30 pm - 7:50 pm	"Gut Epithelial Cells as Participants in Allergy"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Plant Defense Compounds Control a Neuro-Immune Circuit in Allergic Sensitization"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Mechanisms for Initiation of Food Allergy by Skin Pre-Disposed to Atopic Dermatitis"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"Effects of IFNy on IL-10+B Cell Protection Against Eosinophilic Esophagitis"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"B Cell Repertoires and Phenotypes in Food Allergy and Oral Immunotherapy"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Environmental Drivers of Sensitization and Reactivity Discussion Leader:
9:00 am - 9:20 am	"Role of Allergen-Specific B Cell in Cow’s Milk-OIT-Induced Desensitization, Remission, and Natural Outgrowth"
9:20 am - 9:25 am	Discussion
9:25 am - 9:45 am	"Bacterial Metabolites Regulate Allergic Responses to Food"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Diet and Microbiota Drivers for the B Cell Repertoire"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Food Allergy From a Transcriptomic Lens"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Early Life Imprinting of Intestinal Tolerance"
11:30 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Dietary Antigens in Oral Tolerance"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"IL-1ß is Necessary for Indoor Dust-Mediated Airway Sensitization to Peanut"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Human Colon as a Source of IgE in Food-Sensitized Patients."
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	T Cells in IgE and Non-IgE-Mediated Food Allergies Discussion Leader:
7:30 pm - 7:50 pm	"T Cell Responses in Alpha-Gal Syndrome"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:15 pm	"Metabolomics of Food Allergy and Immunotherapy"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:30 pm	"DOCK8 and STAT3 Cooperate to Restrain IgE-Inducing T Follicular Helper Cells"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Immunologic Phenotypes of Food Allergic Diseases"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"A Gamma Delta T cell-IL-3 Axis Controls the Responsiveness of Sensory Neurons to Allergens"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Immunotherapy Outcomes and Mechanisms Discussion Leader:
9:00 am - 9:20 am	"Shining a Light on Early Determinants of Food Allergy: Systems Biology of Early Atopy (SunBeam)"
9:20 am - 9:25 am	Discussion
9:25 am - 9:45 am	"Immune Modulation and the Potential for Remission After Peanut Sublingual Immunotherapy"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Preventing Food Allergy: Moving from Efficacy to Effectiveness"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Biologics in Food Allergy: A Jump Start"
11:05 am - 11:10 am	Discussion
11:10 am - 11:30 am	"Epitope Endgame: Atomic Structure of IgE Epitopes"
11:30 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Targeting T Cells to Treat Food Allergy"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Immunomodulatory Metabolites Differ Over Time and Between Desensitization Outcomes in Children on Peanut Oral Immunotherapy"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Non-Canonical Role of T Follicular Helper Cells in the Maintenance of Peripheral Tolerance"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mast Cells, Basophils and Mechanisms of Reactivity Discussion Leader:
7:30 pm - 7:40 pm	"Mast Cell-Intrinsic TGF-b Signaling Modulates Mast Cell Effector Function and Allergic Responses"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 8:05 pm	"Mast Cells and their Progenitors in Allergic Lung Inflammation"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Pro-Resolving Roles for Basophils and Monocyte-Derived Macrophages in IgE-Mediated Skin Allergy."
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"IgG Antibodies Regulate the Pro-Inflammatory Program of IgE: Allergen-Activated Mast Cells"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	General Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI181371. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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