| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair Aditi Bhattacharya |
| 3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leader: Craig Erickson (Cincinnati Children's Hospital) |
| 3:45 pm - 4:15 pm | Michael Tranfaglia (FRAXA Research Foundation)
"Lost in Translation: How Can Basic Science Cure Disease?"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neuronal and Glial Dysfunction in Fragile X and Other ASD |
| Discussion Leaders: Katrina Kelner (Science Translational Medicine) and Yun Li (MIT) |
| 7:30 pm - 7:50 pm | Abhishek Banerjee (MIT)
"Cell-Type and Circuit-Specific Defects in a Mouse Model of Rett Syndrome"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Julia Berzhanskaya (George Washington University)
"Network Abnormalities in Developing Visual Cortex of a Rat Model of Fragile X Syndrome"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Haruki Higashimori (Tufts University)
"Astrocytes and Autism: Astroglia Glutamate Transporter GLT1 and Synaptic Phenotypes of Fragile X Syndrome"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Tori Schaefer (Cincinnati Children's Hospital Medical Center)
"Signaling Imbalances in FXS and ASD: Bringing the Clinic to the Bench"
|
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | New Paradigms in Signaling, Diagnostics and Therapeutics |
| Discussion Leader: Gul Dolen (Johns Hopkins University) |
| 9:00 am - 9:20 am | Kristy Sawicka (Rockefeller University)
"Signaling Network Rewiring Leads to ERK-Dependent Phosphorylation of RPS6 in Cortex of Fragile X Mice"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sung Han (University of Washington)
"Enhancement of Signaling by GABAA Receptors Having a2,3-Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Yun Li (MIT)
"Modeling Rett Syndrome Using Genetically Engineered Human Pluripotent Stem Cells"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Sein Braat (University of Antwerp)
"Involvement of the GABAA Receptor in Fragile X Syndrome: From Molecular and Electrophysiological Deficits to Therapeutic Potential"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | How Translational Science Develops and Propagates - A Mentorship Panel Discussion |
| Discussion Leader: Abhishek Banerjee (MIT) |
| Panel Members:
- Laura Mamounas (NIH)
- Michael Tranfaglia (FRAXA)
- Katrina Kelner (Science Translational Medicine)
- Gul Dolen (JHU)
- Craig Erickson (Cincinnati Children's Hospital)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
