Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Molecular Mechanisms of FXS and Neurodevelopmental Disorders
3:15 pm - 3:20 pm
Opening Remarks
3:20 pm - 3:35 pm
"The Impact Knockout Mouse Model Suggests a Role for eIF2a-Dependent Translation in Autism Spectrum Disorders"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
"Role of CDH1-APC as a Regulator of FMRP and Protein Synthesis at the Synapse"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cellular and Synaptic Mechanisms of FXS and Neurodevelopmental Disorders
5:30 pm - 5:45 pm
"Synaptic Vesicle Recycling Defects in Models of Fragile X Syndrome"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
"Grik4 Over-Expression Underlies Altered Synaptic Gain and Enhances Basal Activation of Amygdala Circuits"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
"Axon Initial Segment Morphology Regulates Cellular Excitability in Rodent Models of Fragile X Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Regulation of Mossy Fiber-Granule Cell Synaptic Plasticity by a Novel FMRP-Cav3.1 Calcium Channel Association"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Altered Ionotropic Receptor Maturation in the Impaired Auditory Critical Periods of Fmr1 Knockout Mice"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Alterations to the Auditory Brainstem in Fragile X Syndrome"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Network Function in FXS and Neurodevelopmental Disorders
9:00 am - 9:15 am
"Corticostriatal Circuit Defects in Hoxb8 Mutant Mouse Model of Repetitive Behaviors"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Prefrontal Network and Axonal Hypoactivity in a Maternal Immune Activation Model of Autism Spectrum Disorder"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Drosophila FMRP Modulates Energy Metabolism and Mitochondrial Function"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Towards Evaluating Connectivity in Models of Neurodevelopmental Disease: An Optical Imaging Pipeline for Functional Connectivity Analysis Across Development in the Mouse Cortex"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Developmental Changes in EEG Correlates of Auditory Hypersensitivity in a Fragile X Syndrome Mouse Model"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Sound Hypersensitivity and Auditory Circuit Disruption in a Rat Model of Fragile X"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Translational Advances in FXS and Neurodevelopmental Disorders / Mentorship Component: Recent Technical and Conceptual Advances
1:30 pm - 1:45 pm
"Pharmacological Rescue of Translation-Relevant EEG Phenotypes in a Mouse Model of Fragile X Syndrome"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"A Novel EEG Approach to Understanding Expressive Language Deficits in Fragile-X Syndrome"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
Panel Discussion
Recent Technical and Conceptual Advances Within the FXS and NDD Fields and Ramifications on Clinical Aspects
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
