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Fragile X and Autism-Related Disorders (GRS)

Gordon Research Seminar

Lessons From Differences and Similarities in FXS and Other ASDs

May 14 - 15, 2022

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Fragile X and Autism-Related Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is the convergence and disparities of Fragile X Syndrome and other autism spectrum disorders. Through this meeting, we will bring together early stage scientists from multiple fields to discuss and compare mechanisms in ASDs from genetics to human disease, with the goal of fostering new ideas and collaborations that will ultimately advance ASD research.

Related Meeting

This GRS will be held in conjunction with the "Fragile X and Autism-Related Disorders" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm	Molecular Characteristics of FXS and ASDs Discussion Leader:
3:15 pm - 3:25 pm	"Mapping the Developmental Nascent Proteome and Identifying Causal Protein Networks in FXS and Autism Related Disorders"
3:25 pm - 3:30 pm	Discussion
3:30 pm - 3:40 pm	"Identifying Genetic modifiers of FMR1 Silencing in Human FXS Neural Cells"
3:40 pm - 3:45 pm	Discussion
3:45 pm - 3:55 pm	"Modelling ARID1B-Deficiency in Coffin-Siris Syndrome Using Human iPSC-derived Excitatory Neurons"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Synaptic Dysfunctions and Adaptations in FXS and ASDs Discussion Leader:
5:30 pm - 5:40 pm	Introduction by Discussion Leader
5:40 pm - 5:50 pm	"Cell Type-Specific Disruption of Cortico-Striatal Circuitry Drives Repetitive Patterns of Behaviour in Fragile X Syndrome Model Mice"
5:50 pm - 5:55 pm	Discussion
5:55 pm - 6:05 pm	"Nitric Oxide as a Novel Therapeutic Target for Autism Spectrum Disorder (ASD): Focus on Cntnap2 (Caspr-2) Mouse Model"
6:05 pm - 6:10 pm	Discussion
6:10 pm - 6:20 pm	"Modeling From Single Cell Electrophysiology to Neuronal Network Interactions in Human Induced Pluripotent Stem Cell Derived Rett Syndrome and Isogenic Controls"
6:20 pm - 6:25 pm	Discussion
6:25 pm - 6:35 pm	"The Autism Risk Gene Syngap1 Assembles Cortical Circuits by Regulating Intrinsic Membrane Excitability"
6:35 pm - 6:40 pm	Discussion
6:40 pm - 6:50 pm	"Sex-Specific, mGlu5 Receptor-Dependent Dysfunction of Sensory Neocortical Circuits in a Mouse Model of Autism-Spectrum Disorder, Caused by Deletion of PTEN"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:05 pm	"Juvenile Fmr1-Knockout Rats Show Enhanced Feature Encoding in the Cortex"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:30 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Behaviour and Circuit Differences in FXS and ASDs Talks in this session will focus on how mutations that cause FXS and ASDs affect circuitry and networks in the brain, and how these changes manifest in altered behaviours. Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:20 am	"Assessing Gene Transfer in a Mouse Model of SYNGAP1 Haploinsufficiency Associated Disorder"
9:20 am - 9:25 am	Discussion
9:25 am - 9:35 am	"Social Behavioral Deficits in Preclinical Neurofibromatosis Type 1: Awake-behaving Corticoaccumbal Recordings and Optogenetic Rescue"
9:35 am - 9:40 am	Discussion
9:40 am - 9:50 am	"GDF11 Expression Level Modulates Neurological Behavior and is Regulated by MeCP2"
9:50 am - 9:55 am	Discussion
9:55 am - 10:05 am	"Multimodal Temporal Pattern Discrimination in Awake-Behaving Mice"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Auditory Temporal Processing Across Development in Two Different Mouse Models of Autism"
10:20 am - 10:25 am	Discussion
10:25 am - 10:35 am	"Deletion of Autism-Related Genes in the Auditory Brainstem Contributes to Sound-Driven Cortical EEG Abnormalities and Can Be Prevented by Low-Level Expression"
10:35 am - 10:40 am	Discussion
10:40 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Alternative Models for Fragile X and ASDs / Panel Discussion: Career Development Discussion Leader:
1:30 pm - 1:40 pm	"Rapid Assessment of the Temporal Function and Phenotypic Reversibility of Neurodevelopmental Disorder Risk Genes Using Auxin-Inducible Degradation in C. elegans"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 1:55 pm	"Modelling Koolen-de Vries Syndrome in Cerebral Organoids"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:30 pm	Panel Discussion Career Development
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD102087. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Fragile X and Autism-Related Disorders

June 14 - 19, 2026

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