Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Molecular Pathogenesis of FXS and ASD
3:15 pm - 3:25 pm
"Molecular Consequences Driving Neurological Deficits Caused by Changes in MeCP2 Levels"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Fmr1-/y and Syngap+/- Mouse Models Exhibit Divergent Translation Environments and Deficits of Synaptic Plasticity"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"The Role of Astrocyte BMP Signaling in Fragile X Syndrome Model Mice"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Advances in Genetics and Functional Genomics and Behavior and Circuit Dysfunction in FXS and ASD
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 5:50 pm
"Identifying Genetic Modifiers of Seizures in Fragile X Syndrome Through Whole Genome Sequencing and Functional Testing"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:05 pm
"Development of an Ovine Model of Fragile X Syndrome for Biomarker Discovery and Therapeutic Testing"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:20 pm
"Heterozygosity for Neurodevelopmental Disorder-Associated TRIO Variants Leads to both Shared and Distinct Deficits in Behavior, Neuronal Development, and Synaptic Transmission in Mice"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
"Altered Physiology of Primary Visual Cortex in Fragile X Syndrome Revealed by Field Potential Recordings"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
"Neocortical Excitation/Inhibition Imbalance During Early Development Leads to Permanent Socio-Behavioral, Transcriptomic and Connectivity Alterations"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
"Visual Discrimination in FXS: Insights from Behavior and EEG"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Body-Brain Interactions in FXS and ASD and Advances in Therapeutic Strategies for FXS and ASD
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Impaired Baseline and Induction Kinetics of the Cellular Stress Response in Rett Syndrome"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Effects of Nf1 on Sleep Behavior are Mediated through Starvation and SARM1 Dependent NAD+ Metabolism"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Examining the Role of Specific NMDA Receptor Subunits in Cortical Circuit Dysfunction in Fragile X Syndrome"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Results from a Double-Blind, Randomized, Placebo-Control Trial of Lovastatin and Minocycline in Fragile X Syndrome"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Negr1: A New Possible Convergent Hub for Autistic Spectrum Disorders"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"A Combination of Multi-Electrode Array (MEA) and Live Mouse Tracker (LMT) as a Versatile Drug Screening Platform for Fragile X Syndrome"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Panel Discussion Careers in Biomedical Sciences
1:30 pm - 2:30 pm
Panel Discussion
Careers in Biomedical Sciences
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes