Probing and Controlling Gene Regulation in Space and Time

In the past decades, we have witnessed rapid research progress in deciphering the fundamental mechanisms governing the 3-dimensional organization of eukaryotic genomes within the nucleus and their roles in gene expression, genome stability and cell division. Understanding such principles provides deeper insights into normal development and physiology, and their deregulation in disease. Ongoing efforts aim to improve the resolution of analyses towards single cells and multi-dimensions to reveal the systems-level complexity in gene regulation. As a result, the rich information encoded in the complex gene regulation through space and time is being uncovered. How to harness such information to advance the knowledge of our genome and to achieve disease treatment remains a challenging task. The 2025 conference on Genome Architecture in Cell Fate and Disease: “Probing and Controlling Gene Regulation in Space and Time” is the fifth meeting of this series that aims to inspire discussion in the field of 3D genome organization. Specific focus will be placed on mechanisms of genome organization, gene regulation in development, 3D genome in fundamental processes such as DNA replication and repair, chromatin dysfunction in disease, technology development, data integration and modelling.