| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Exploring the Role of DNA Replication and Repair in Cancer |
| Discussion Leaders: Darshil Patel (Cornell University, USA) and Mrinal Srivastava (University of Texas MD Anderson Cancer Center, USA) |
| 3:45 pm - 4:20 pm | Thanos Halazonetis (University of Geneva, Switzerland)
"DNA Replication Stress in Cancer and Relevant Repair Pathways" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Emerging Trends in DNA Repair |
| Discussion Leader: Shrestha Ghosh (The University of Hong Kong, Hong Kong SAR China) |
| 7:30 pm - 7:45 pm | Wai Chung (Justin) Leung (University of Texas at Austin, USA)
"ZMYM3/ZNF261 Promotes Homologous Recombination via BRCA1-A Complex Axis" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Liwei An (The University of Hong Kong, Hong Kong SAR China)
"USP7 Enforces RNF169-Dependent DNA Double-Strand Break Responses" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Carl Schiltz (Cornell University, USA)
"Structural and Functional Insights into the OLD Family Endonucleases" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Brittany Haynes (Barbara Ann Karmanos Cancer Institute, USA)
"Targeting Rad6 Sensitizes Triple Negative Breast Cancer Cells to Cisplatin by Attenuating Translesion Synthesis and Fanconi Anemia Network Mediated Repair" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Jirawas Sornkom (Peter MacCallum Cancer Centre, Australia)
"Dual Targeting of RNA Pol I and BET Proteins at the rDNA as a Highly Effective Therapeutic Strategy for the Treatment of Acute Myeloid Leukaemia" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Hui Li (Shanghai Children's Medical Center, China)
"Negative Feedback-Defective PRPS1 Mutants Drive Thiopurine Resistance in Relapsed Childhood ALL" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Chromatin Dynamics and DNA Replication |
| Discussion Leader: Naveed Ishaque (German Cancer Research Institute, Germany) |
| 9:00 am - 9:15 am | Deepti Sharma (Nanyang Technological University, Singapore)
"PARP1-Nucleosome Binding Kinetics Are Influenced by the Histone Protein Composition" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Dongsung Kim (Cornell University, USA)
"Methyltransferase-Like METTL13 Associates with Claspin and Is Required for Proper Genome Replication and Chromatin Dynamics" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Jigar Bandaria (University of California, Berkeley, USA)
"Super-Resolution Imaging Reveals Shelterin Mediated Compaction of Telomeric Chromatin Protects Chromosome Ends" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Gustavo Santoyo (Universidad Michoacana de San Nicolás de Hidalgo, Mexico)
"Spo11 Is Required for Elevated Mutation Rate During Meiosis in Saccharomyces cerevisiae" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Lana Talmane (The University of Edinburgh, United Kingdom)
"The Landscape of Replication-Associated Mutations in Human and Mouse Germlines" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Giulia Saredi (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
"H4 K20me0 Marks Post-Replicative Chromatin and Recruits the TONSL-MMS22L DNA Repair Complex" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Panel Discussion |
| Discussion Leaders: Catalina Pereira (Cornell University, USA) and Jessica Woodward (University of Edinburgh, United Kingdom) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Exploring Your Options: Personal-Professional Life Balance in Academia and Industry" |
|
- Anindya Dutta (University of Virginia, USA)
- Eric Lightcap (Takeda Pharmaceuticals International, USA)
- Thanos Halazonetis (University of Geneva, Switzerland)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
