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Genomic Instability (GRS)

Gordon Research Seminar

Chromosome Replication, Repair and Organization in the Maintenance of Genome Stability

July 21 - 22, 2018

Chairs

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Conference Description

The Gordon Research Seminar on Genomic Instability seeks to bring together graduate students, post-docs and other early-stage researchers in an informal setting to present and exchange new data and cutting-edge ideas. The atmosphere of the GRS provides a friendly forum for discussion with peers and mentors and sets Gordon Research Seminars as an exclusive opportunity for young scientists.

The second edition of the Genomic Instability GRS will focus on understanding how the molecular mechanisms underlying DNA replication, repair and chromosomal organization act together to preserve genome stability. The program will feature a keynote seminar by Professor Susan Gasser as well as selected scientific talks and poster presentations by students and postdocs. Further, career opportunities will be explored during a panel discussion with scientists from academia and industry.

Related Meeting

This GRS will be held in conjunction with the "Genomic Instability" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Risks Arising from Replication Stress Discussion Leader:
3:45 pm - 4:20 pm	"How Heterochromatin and BRCA1 Prevent Satellite Repeat Transcription, R-Loops and Instability: Risks Arising from Replication Stress"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Molecular Mechanisms of DNA Repair Discussion Leaders: and
7:30 pm - 7:45 pm	"Cell Cycle Regulation of the Mus81-Mms4 Endonuclease During Joint Molecule Resolution"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Non-Essential Function of the Conserved BRCA2 DNA-Binding Domain"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Fate of an Unrepaired Broken Chromosome in Fission Yeast"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"A RecQ Helicase in Disguise: The Unconventional Structure and Function of the Human Genome Caretaker RecQ4"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Double-Stranded DNA Breaks with 5' Overhangs Skew End-Joining Towards Alternative End-Joining Leading to Chromosomal Translocations in Mouse B Cells"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Nucleolar Double Strand Break Repair Relies on a Specialized DNA Damage Response Deviating from the Canonical DNA Damage Response"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Genomic Instability and Disease Discussion Leaders: and
9:00 am - 9:15 am	"Nelf-E Is Recruited to DNA Double-Strand Break Sites to Promote Transcription Repression and Repair"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"An ATM Dependant Role for B-Myb in the Maintenance of Genome Stability During S Phase in Embryonic Stem Cells"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Association of DNA Damage, Repair and Accumulation of Chromosomal Aberration with Acquisition of Resistance to Escalating Doses of Imatinib in Leukemic Cells"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"RAD51 Mutations Reported in Tumors and Fanconi Anemia Patients Cause a Range of Cellular Defects"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Retinoblastoma Protein Maintains Epigenetic Features to Modulate Carcinogen Susceptibility and Genomic Stability"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Regulation of BRCA1 by SIRT2"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career and Grantsmanship Panel Discussions Discussion Leader:
1:30 pm - 2:00 pm	Panel Discussion Career Possibilities
2:00 pm - 2:30 pm	Panel Discussion Grantsmanship
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

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