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Genomic Instability (GRS)

Gordon Research Seminar

The Influence of Chromosome Architecture and Cell Cycle on Repair and Maintenance of the Genome

July 9 - 10, 2022

Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Genomic Instability is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. Attendance at the Genomic Instability GRS is a highly recommended prelude to the Genomic Instability GRC.

This meeting will highlight the influence of chromatin state and cell cycle on pathways that signal and repair DNA double-strand breaks and damage associated with replication stress. Additionally, this GRS will feature a keynote presentation by Dr. Irene Chiolo and selected talks and posters by graduate students and post-doctoral researchers. There will also be a career panel discussion with researchers from academia and industry.

Related Meeting

This GRS will be held in conjunction with the "Genomic Instability" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Chromatin and Nuclear Dynamics During DNA Repair Discussion Leader:
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:20 pm	"Highways for Heterochromatin Repair"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Genomic Integrity, Chromatin and Nuclear Dynamics during DNA Repair Discussion Leader:
7:30 pm - 7:45 pm	"Unprocessed Ub-PCNA Promotes Break-Induced Replication at Telomeres in ATAD5-deficient ALT Cancer Cells"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Double-Strand Break Repair Pathway Choice Dictates Cell Death Outcomes After Ablative Radiotherapy"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Elucidating Mechanisms of Non-Canonical CDK8 Function in DNA Damage Signaling"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"DNA Damage-Induced Nuclear Envelope Rupture: a New Cancer Vulnerability"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Insight into the mechanistic processes of the TC-NER pathway"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"The Histone Demethylase KDM5A Promotes DNA Repair Activities Including Transcriptional Silencing via Poly(ADP-Ribose) Binding and macroH2A"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	DNA Repair by Homologous Recombination, During Transcription and Replication Stress Discussion Leader:
9:00 am - 9:15 am	"Autologous K63-Deubiquitylation Within the BRCA1-A Complex Licenses DNA Damage Recognition"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Short-Range End Resection Requires Proper PCNA Unloading for Faithful Homologous Recombination Repair"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"R-loop-Mediated Recruitment of Cohesin and CTCF as a Potential Regulator of Genome Structure and DNA Repair."
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"ATAD5 Functions as a Regulatory Platform for Ub-PCNA De-ubiquitination"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Phosphorylation of SAMHD1 Thr592 Increases C-Terminal Domain Dynamics, Tetramer Dissociation, and ssDNA Binding Kinetics"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Role of ARIP4 in Transcriptional DSB Regulation"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Paths for Scientists Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Career Paths for Scientists
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Genomic Instability

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