Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Glial Control of Circuit Remodeling
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Identifying Modifiers of Microglial Multitasking in Aged Brain"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Microglia Coordinate OPC-Synapse Interactions to Remodel Circuits in the Adult Brain"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mechanisms by Which Oligodendrocyte Precursor Cells Sculpt the Form and Function of Visual Circuits"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Tweek/LPD-3-Mediated ER-PM Contact Site Formation Facilitates Lipid Transfer and Glial Phagocytosis during Neuronal Remodeling"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glial Development and Specification
9:00 am - 9:20 am
"How Developmental Origin and Local Environment Influence Astrocyte Heterogeneity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Genetic Mechanisms that Shape Glia during Nervous System Construction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Glial Orchestra: Insights From Human Brain Variation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Targeting Diverse Macrophage in the Central Nervous System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"4D Marmoset Brain Map Reveals MRI and Molecular Signatures for Onset of Multiple Sclerosis-Like Lesions"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Transcriptional and Regulatory Landscape of Human Astrocyte Evolution"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanisms Underlying Astrocyte Heterogeneity in the Mouse Cerebral Cortex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuro-Immune Interactions and Glia
7:30 pm - 7:50 pm
"Extracellular Matrix Regulation of Synapses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Deconstructing Astrocyte-Neuron Connectivity in Health and Parkinson’s Disease"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"An Astrocyte Murder Mystery: How and why Microglia Kill Healthy Astrocytes During Retinal Development"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Consequences of Molecularly Defined Reactive Astrogliosis in vivo"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Pathogenic Oligodendrocytes Drive Human Cognitive Decline in Aging"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glial Control of Behavior
9:00 am - 9:20 am
"Astrocytes in High Brain Functions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Norepinephrine Changes Behavioral State via Astroglial Purinergic Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dissecting the Contribution of Astrocytes to the Synaptic and Behavioral Effects of Neuromodulators"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Astrocyte Regulation of Pain Behavior"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Role of Astrocytic Adrenergic Receptors in Modulation of Chronic Pain"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Effects of Satellite Glial Cell Signaling and Stimulation on Isolated DRG Nociceptors"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Exploring the Role of Calcium in Learning-Induced Myelin Dynamics and Behavior"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glial Regulation of Circuit Function
7:30 pm - 7:50 pm
"Arousing Astrocytes Alters Neural Circuit Computations"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Cell Type-Specific Functions of Chromatin Remodeler Chd1 in the Temporal Control of Homeostatic Plasticity"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Dorsal Raphe Astrocytes Regulate Cortical Neuronal States"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"K+ Buffering Impairment Disrupts Cortical Neuron Excitability"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Astrocytes are "Excited" in the Seizing Brain"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Glial Signaling to Neurons and Other Glial Cells
9:00 am - 9:20 am
"Molecular Organization of Astrocyte Connectivity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cell Biology and In vivo Dynamics of Astrocyte-secreted Extracellular Vesicles (EVs) in the CNS"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Role of Exocytosis in Oligodendrocyte Development and Plasma Membrane Damage Repair"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Role of Astrocytes in Active and Silent Synapse Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Wired Differently: How Sex, Estrogen, and Opioids Shape Astrocyte-Mediated Synaptic Development"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"BDNF/TrkB.T1 Signaling Regulates Astrocyte and Neuronal Plasticity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dynamics of Sleep, Feeding, and Metabolic Homeostasis in Drosophila Ensheathing Glia, Astrocytes, and Neurons"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Tools for Glial Biology
7:30 pm - 7:50 pm
"Imaging Astrocyte-Neuron Interaction with Genetically Encoded Indicators"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Large Scale Production of IPSC-Derived Human Oligodendrocyte Cell Banks and Myelinating Co-Cultures for "Off-The-Shelf" Drug Screening"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Quantification and Analysis of Molecular Spatiotemporal Signals with Machine Learning Techniques"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Bioluminescent-Optogenetic Manipulation of Astrocyte-to-Neuron Signaling for Memory Consolidation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Viral Tools for Glial Manipulation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Glial Contributions to Disease
9:00 am - 9:20 am
"Molecular Mechanisms by which Glia Modulate Neuron Properties and Degeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lesion-Remote Astrocytes Govern Microglia-Mediated White Matter Repair"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mouse Genetic Approaches to Study Neuronal Vulnerability Following Remyelination Failure"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Intrinsic Astrocyte Dysfunction Caused by Highly-Penetrant Multiple Sclerosis (MS) Gene Variants"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Novel ASD Risk Genes with Potential Astrocytic Roles"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Brain Macrophage Transplantation for Research and Therapy Development"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Astrocyte Dysfunction in Down Syndrome and Alzheimer's Disease: Roles for Astrocyte-Secreted Pleiotrophin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Glia in Brain Physiology and Homeostasis
7:30 pm - 7:50 pm
"Dynamic Brain Endothelial Cell - Astrocyte Endfoot Communication as a Bridge between the Body and the Brain"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Role of Glia in Brain Physiology and Homeostasis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Astrocytic Signaling and Gliovascular Dynamics in Sleep"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Astrocytic Metabolic Control of the Sleep/Wake Cycle"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Elusive Functional Roles of Astrocytes"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure