Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Biophysics of Glyco- and Sphingo-Lipid Biology
The goal of this session is to summarize the present state of the field and identify the major challenges for the future and the techniques, many of them interdisciplinary, that will be needed to address the underlying biophysical mechanisms that define glyco- and sphingo-lipid biology.
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"The Molecular Structure of Fluid Phase Sphingomyelin Bilayers"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Ganglioside Neurotrophic Properties and the Microenvironment of TrkA in Neuroblastoma Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Role of the Plasma Membrane Phenotype in Cellular Physiology"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Atypical Versus Canonical Sphingolipids: Do They Behave the Same?"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Biochemistry of Glyco- and Sphingo-Lipid Biology
The metabolism of glycolipids and sphingolipid is complex and several of the metabolic intermediates are bioactive signaling molecules. Therefore, it is necessary to understand the regulatory mechanisms controlling their metabolism.
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Complexity of Sphingolipid Metabolism and Regulation: Metabolic Cross-Talk Between Sphingolipid and Sterol in Lipid Domains"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"No Brain No Pain - Headless Sphingolipids and Neuropathies"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Heteromeric Complex Between Sphingomyelin Synthase 1 and Glucosylceramide Synthase Regulates Ceramide Metabolism"
10:35 am - 10:45 am
Discussion
10:45 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Dendritic Cells Are the Metabolic Gatekeepers of Thymic Egress"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Ceramide Molecules Self-Assemble to Form Large Stable Channels in Glycerophospholipid Membranes"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Defining the Functions of ORM Proteins as Regulators of Sphingolipid Metabolism Through Development and Characterization of Arabidopsis Loss-of-Function Mutants"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Metabolism and Trafficking of Glyco- and Sphingo-Lipids
The session synergizes with the themes of session 2, by relating sphingolipid metabolism to cellular and organismal functions.
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Molecular Dissection of Ceramide-Induced Mitochondrial Apoptosis Using Photoactuated Lipid Probes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Long-Chain Base Metabolism and Alpha-Oxidation in the ER"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Crosstalk Between Glycosphingolipids and Protein Glycosylation: A New Model of IgA Nephropathy"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Obesity, Inflammation and Diabetes: The Connection Is Sphingolipids
The session covers the controversial sphingolipid metabolic link between obesity, inflammation and diabetic complications.
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:45 am
"The Adipocyte: A Central Modulator of the Ceramide-Insulin Resistance Axis, and Beyond"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Modulation of Metabolic Disease by Regulation of Intestinal Ceramide Production"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Atypical 1-Deoxysphingolipids in Anoxia Survival"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Structure and Function of Adiponectin Receptors"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Role of Adipose Ceramides in Metabolic Diseases"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Glucagon Receptor Antagonism Decreases Lipotoxicity"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Understanding the 3 "I"s of Glycolipids and Sphingolipids: Inflammation, Infection, Immunity
This session covers the roles of glyco- and sphingo-lipids in bacterial and viral infections as well as underlying mechanisms of innate immunity and inflammation.
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Bioactive Sphingolipid Metabolism: The Plot Thickens"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"New Paradigm for Chronic Inflammation Mediated by Ganglioside Molecular Species"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"The Lipid Matrix at the Host-Pathogen Interface"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Sphingolipids, Mitochondria and Brain Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Sphingosine and Sphingolipids in Pulmonary Bacterial Infections"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Roles for Sphingolipid Metabolites: Autophagy and Mitophagy
Session in memory of Shimon Gatt. Sphingolipid metabolites have recently been identified as mediators of endocytic membrane trafficking, autolysosome destabilization and autophagy.
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Sphingolipids in Connecting Autophagic and Endolysosomal Pathways to Noncanonical Cell Death"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Novel Regulators of Sphingolipid Metabolism and Function"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Ceramide-Associated Tubulin in the Regulation of Mitochondria"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Sphingosine Kinase 1 in Endocytic Membrane Trafficking and p53-Dependent Autophagic Cell Death"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Small Molecule Modulators of S1P Chemotactic Gradients"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"The Role of C16:0 Ceramide in the Development of Obesity and Type 2 Diabetes: CerS6 Inhibition as a Novel Therapeutic Approach"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Sphingolipid Control of Mitophagy and Lysosomal Degradation in Lung Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Approaches to Glycolipid and Sphingolipid Biology - Spectrometric, Structural and System-Based Approaches
Glycolipid and sphingolipid metabolic networks are complex and their study requires novel technologies.
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Life-Cell Detection of Sphingolipid Metabolizing Enzymes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Co-Deficiency of the Acid Sphingomyelinase Ameliorates Farber Disease"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
"Functionalized Lipids for Investigations of Lysosomal Lipid Trafficking"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Genome-Wide CRISPR Screening for Identifying Genes Involved in Glycolipid Metabolism"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Click Chemistry to Monitor Dynamic Redistribution of Sphingolipids in Host Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dysfunctional Glyco- and Sphingo-Lipid Metabolism in Cancer
Three NIH NCI program project grants investigate dysfunctional sphingolipid metabolism in solid and non-solid tumors. Several of these P01 grants have led to therapeutic modalities that are now in the clinic in phase I/II studies.
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Enzymes of Sphingolipid Metabolism as Targets in Cancer Therapy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Dysfunctional Sphingolipid Metabolism in AML, a Team Approach"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"ORMDLs/Orms: Direct Sensors and Regulators of Sphingolipid Biosynthesis in Cancer"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Development of Novel Cancer Therapeutics by Targeting Sphingolipid Signaling"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Inhibitory Role of SMS2 in Mouse Cancer Models"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Mass Spectrometry Imaging Localization of Ganglioside Signatures in Mouse Brain following β-Galactosidase Knock Out"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"A Role for CerS6 on the EMT Spectrum"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Roles for Glycolipids in the Sphingolipid Storage Diseases
Several important inheritable diseases are directly related to dysfunctional glycolipid and sphingolipid metabolism.
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Cellular Functions of GlcCer and GBA2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Glucosylceramide, More than a Membrane Lipid"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Quality Control of Glucosylceramide by EGCrP1 Is Related to the Pathogenicity of Cryptococcus neoformans "
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"An Unexpected Role of Complement in Glucosylceramide Metabolism"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"RNA-Seq Analysis of Microglia and Brain in Various Lysosomal Storage Diseases"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure