| Sunday evening - June 28 |
7:30 - 9:45 pm |
| Welcome Reception |
9:45 pm - 12:00 am |
| Session Title: |
Toward an integrated model of hemostasis |
- J. Evan Sadler (Discussion Leader)
- George J. Broze - The coagulation cascade in mouse models
- Charles T. Esmon - New insights into the regulation of the protein C activation complex on endothelium
- Sanford J. Shattil - Integrin signaling in hemostasis: the rules of engagement
- Michael A. Gimbrone - Hemodynamic forces and endothelial gene regulation
| Monday morning - June 29 |
9:00 - 12:15 |
| Session Title: |
Platelet signaling pathways |
- Lawrence F. Brass (Discussion Leader) - Signaling through protease-activated receptors
- John H. Hartwig - Signals controlling platelet actin assembly
- Kenneth Lerea - Control of platelet function by seryl/threonyl phosphatases: Role of beta3 threonine phosphorylation (BRIEF UPDATE - 10 min.)
- Philip W. Majerus - Intracellular signalling by phosphatidylinositols
- Satya P. Kunapuli - Molecular basis for ADP-induced platelet activation
- Hans-Michael Jantzen - Two distinct receptors mediate ADP-dependent platelet aggregation, one P2Y1-like, the other Gi-coupled (BRIEF UPDATE - 10 min.)
| Monday evening |
7:30 - 9:45 pm |
| Session Title: |
Novel gene and protein therapies for hemostatic and vascular disorders |
- Katherine P. Ponder (Discussion Leader) - Retroviral vectors for gene therapy for plasma protein deficiencies
- Katherine A. High - AAV-mediated gene transfer for hemophilia B
- Thomas S. Edgington - Delivery of thrombogenic function to selected vascular beds: An approach to solid tumor eradicative therapy
- Victor Dzau - Inhibition of cellular proliferation in vessel grafts with antisense oligonucleotides to cell cycle transcripts
| Tuesday morning - June 30 |
9:00 - 12:15 |
| Session Title: |
Integrins and platelet communications |
- Mark Ginsberg (Discussion Leader) - Integrin cytoplasmic domains: the shape of things to come
- Debbie A. Law - Tyrosine phosphorylation in GP IIb-IIIa signaling
- Tatiana V. Byzova - Ligand recognition control by activation states of α
vß3 (BRIEF UPDATE - 10 min.)
- Samuel A. Santoro - Ligand recognition by cell surface collagen receptors
- Joan E. B. Fox - Signaling induced by GPIb-IX and integrins. Involvement of calpain and Rho family members
- Sacha M. Dopheide - Calpain proteolysis of platelet GPIb/V/IX: a novel mechanism regulating platelet rolling, adhesion and thrombus formation under flow (BRIEF UPDATE - 10 min.)
| Tuesday evening - June 30 |
7:30 - 9:45 pm |
| Session Title: |
Genes, development, and hemostasis |
- David Ginsburg (Discussion Leader) - Combined factors V and VIII deficiency due to mutations in a resident protein of the ER-Golgi intermediate compartment
- Shaun Coughlin - Lessons from protease-activated receptor knockouts
- John P. Sheehan - The zebrafish as a genetic model for hemostasis (BRIEF UPDATE - 10 min.)
- Peter Carmeliet - Gene targeting of membrane proteins in the blood clotting and anticoagulant pathways
- Hartmut Weiler-Guettler - Consequences of a prethrombotic state in mice with APC-deficiency
| Wednesday morning - July 1 |
9:00 - 12:15 |
| Session Title: |
Cell surfaces and cell-cell interactions |
- Charles T. Esmon (Discussion Leader)
- Michael P. Lisanti - caveolae, signaling, and cell transformation
- Peter J. Newman - Adhesive and signaling properties of PECAM-1
- Denise E. Jackson - Recruitment and activation of the protein-tyrosine phosphatase SHP-1 by PECAM-1 (BRIEF UPDATE - 10 min.)
- Becky J. Fredrickson - Functional role of glycoprotein V and high shear in modulating von Willebrand factor-platelet glycoprotein Ib-IX-V complex interactions under dynamic conditions (BRIEF UPDATE - 10 min.)
- Simone M. Schoenwaelder - Platelet glycoprotein Ib/IX: a unique shear-resistant rolling receptor - studies with GPIb/IX-transfected CHO cells (BRIEF UPDATE - 10 min.)
- Rodger P. McEver - Cell adhesion and signaling through selectins
- Peter J. Sims - Structure and function of plasma membrane phospholipid scramblase: a protein mediating the cell surface exposure of procoagulant phospholipids
| Wednesday evening - July 1 |
7:30 - 9:45 pm |
| Session Title: |
Structure and function of protein domains |
- Edwin L. Madison (Discussion Leader) - Rational design of zymogen-like variants of tissue-type plasminogen activator
- Glen Spraggon - Crystal structures of fibrinogen fragments
- Kathleen P. Pratt - Gamma chain dysfibrinogenemias: Molecular structure-function analysis of naturally occurring mutations in the gamma chain of human fibrinogen
- Zaverio M. Ruggeri - Structural analysis of the von Willebrand factor A1 domain-glycoprotein Ibα interaction
- R.M. van der Plas - Which residues of the vWF A3 domain are involved in binding to collagen type III? (BRIEF UPDATE - 10 min.)
| Thursday morning - July 2 |
9:00 - 12:15 |
| Session Title: |
Megakaryocytes and the birth of platelets |
- Kenneth Kaushansky (Discussion Leader) - Molecular mechanisms of megakaryocyte development
- Ramesh A. Shivdasani - Transcriptional control of platelet biogenesis
- Katya Ravid - Transcriptional mechanisms responsible for thrombopoietin effects on platelet production
- Paula B. Tracy - Secretable human platelet-derived factor V originates from the plasma pool (BRIEF UPDATE - 10 min.)
| Thursday evening - July 2 |
8:00 - 9:00 pm |
| Joint Party with Vascular Biology |
9:00 pm - 12:00 am |
| Keynote address |
- Mario R. Capecchi - How do hox genes specify our body plan?
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