Sunday evening 7:30 - 10:00 PM | Megs and More |
Discussion Leader: Morty Poncz
- Morty Poncz - Familial platelet disorders: AML-1 defects
- Joe Italiano (Hartwig Lab) - Mechanics of platelet formation
- Jay Silveira (Tracy lab) - Platelet factor V is structurally distinct from plasma factor V [Brief update]
- Mitch Weiss - GATA-1 and FOG in megakaryocytopoiesis and platelet formation
- David Wilcox - Use of the aIIb promoter in retroviral constructs
Monday morning 9:00 - 12:30 PM | Activation and Secretion |
Discussion Leader: Skip Brass
- Stefan Offermans - Platelet defects in mice lacking Gq family members
- Jing Yang (Brass lab) - Defects of platelet function in mice that lack the G protein, Gz [Brief update]
- Hans-Michael Jantzen - Impaired platelet activation in Gai2-deficient mice [Brief update]
- Beverly Koller - Signaling through platelet ADP receptors: lessons from P2Y1 knockout mice
- Pamela Conley - Cloning the elusive platelet ADP receptor that inhibits cAMP formation [Brief update]
- Guy Reed - Secretory mechanisms in platelets
- Rob Flaumenhaft - Regulation of platelet secretion
Monday evening 7:30 - 10:00 PM | Events at the Wall |
Discussion Leader: David Ginsburg
- Zaverio Ruggeri - Adhesion and activation under the stress of shear
- Su Kulkarni (Jackson lab) - A revised model of platelet aggregation [Brief update]
- Evan Sadler - VWF-Ib interactions
- Xiaoping Du - GP Ib signaling - 14-3-3 proteins
- Michael Kroll - A glycoprotein Ib-based signaling complex regulated by shear stress [Brief update]
- Bruce Furie - Lessons from the PSGL-1 knockout mouse
Tuesday morning 9:00 - 12:30 PM | Proteases, etc. |
Discussion Leader: Barbara Furie
- Barbara Furie - Prothrombin:phospholipid interactions - structure and function
- John Morser - Structural Basis for the Anticoagulant and Antifibrinolytic Activity of the Thrombin-Thrombomodulin Complex [Brief update]
- George Broze - Protein Z -dependent protease inhibitor
- Hans Prydz - Factors VIIa and Xa induce cell signaling leading to upregulation of immediate early genes in HaCaT cells [Brief update]
- Wolfram Ruf - Gene induction by coagulation factor Xa is mediated by activation of PAR-1[Brief update]
- Jay Degen - Tissue repair defects in mice lacking specific hemostatic factors
- Sidney Strickland - Plasminogen activators and the brain
Tuesday evening 7:30 - 10:00 PM | Chair's Choice |
Discussion Leader: Skip Brass
- Anne Angelillo-Scherrer - GAS6(-/-) mice and thrombosis
- Ingrid Hrachovinova (Wagner lab) - Soluble P-selectin promotes procoagulant state in mice [Brief update]
- Chuck Esmon - Application of the protein C pathway to the diagnosis and treatment of thrombotic disease
- Peter Sims - Secrets of scramblase
- Tom Deuel - Pleiotrophin
Wednesday morning 9:00 - 12:30 PM | Signals and Cytoskeleton |
Discussion Leader: Sandy Shattil
- Ken Clemetson - GP VI as a platelet receptor for collagen
- Steve Watson - FcR-g chain and other mediators of collagen signaling in platelets
- Gary Koretzky - Collagen signaling: lessons from the SLP-76 knockout mouse
- Joan Fox - Regulation of the platelet cytoskeleton
- Elaine Bearer - Molecular mechanisms of actin synamics in platelets and megakaryocytes [Brief update]
- Charles Abrams - Pleckstrin and the platelet cytoskeleton
Wednesday evening 7:30 - 10:00 PM | Hyper Hemostasis |
Discussion Leader: Kathy High
- David Ginsburg - Thrombosis in the Factor V (Leiden) mouse
- Ulrich Walter - Hyperactive platelets in the VASP knockout mouse
- David H. Farrell - Association of gA/g' fibrinogen levels with coronary artery disease [Brief update]
- Paul Bray - The impact of inherited polymorphisms of platelet aIIbb3
- Tom Kunicki - The impact of inherited polymorphisms of platelet a2b1
Thursday morning 9:00 - 12:30 PM | Integrins |
Discussion Leader: Jo Fox
- Sandy Shattil - Activation of aIIbb3 in platelets
- Mark Ginsberg - Regulators of integrin activation
- Kris Reedquist - Rap I: A regulator of integrin-dependent adhesion
- Robert T. Dorsam (Kunapuli lab) - Comparison of phorbol ester and agonist-induced fibrinogen receptor activation in human platelets [Brief update]
- David Phillips - Signaling through the tail of aIIbb3
- Joel Bennett - Cytoskeleton and the activation of aIIbb3
Thursday evening 7:30 - 10:00 PM | Therapeutic Applications |
Discussion Leader: Paul Bray
- Kathy High - Gene therapy for hemophilia B
- Richard Selden - Gene therapy for hemophilia A
- George Vlasuk - IIa/TF/VIIa inhibitor
- Aaron Marcus - Applications of CD39
Departure after breakfast
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