Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Initiating Events in Hemostasis and Thrombosis
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Initiation of Contact Activation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mechanisms of Platelet Alpha and Dense Granule Biogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Contact Pathway Activation and Polyphosphate"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contributions from the Blood and Vasculature
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Regulation of Endothelial Exocytosis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Making and Measuring the Effect of Mutations on a Massive Scale"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:15 am
"Fibrin/GPVI Interactions in Thrombosis and Hemostasis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Combining Immunohematology and Biophysics to Better Understand Immune-Mediated Blood Cell Disorders: Lessons Learned from HIT"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A Chromosome 5 Cis-Regulatory Element Regulates Mouse Platelet PAI-1 Expression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Interactions Between Blood and Platelets
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Role of Aging and Inflammation in Platelet Activation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Emerging Concepts in Immune-Mediated Thrombotic Thrombocytopenic Purpura"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Platelet/Fibrin Interactions During Thrombosis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Contributions to Hemostasis and Thrombosis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Alterations in von Willebrand Factor and Redox State in Sickle Cell Disease"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Zymogen Factor XII and Neutrophil Functions"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"The Dynamics of Protease Activated Receptor (PAR) Activation and Signaling"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Role of VWF Glycans in Regulating Clearance"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mechanisms of Altered Platelet Production During Inflammation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advanced Models of Coagulation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Insights into the Pathophysiology of Thrombosis Using Mice with Impaired Anticoagulation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Regulating Intra-Clot Thrombin and Fibrin Production Under Flow"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mathematical Models of Coagulation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New and Emerging Therapeutic Targets
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Oral Therapy for Hemophilia"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Novel Anticoagulants Through Allosteric Regulation of Coagulation Proteases"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Targeting FXa with Aptamer-Small Molecule Active Site Inhibitor Pairs for Potent and Reversible Anticoagulation"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Assessing the Benefit of Emicizumab for the Treatment of Hemophilia A: From Lab to Label"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Platelet-Like Particles for Hemostasis and Wound Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
"The Effect of Rigid Red Blood Cells on Platelet Margination and Adhesion in Flow"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Crystal Structure and Allosteric Activation of ADAMTS13"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Design of Biomaterials-Based Technologies for Intravenous Mitigation of Trauma-Associated Hemorrhage and Coagulopathy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Uncovering the Unique Functional APC-Resistant Modifications of Pseudonaja textilis Factor V"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Context Matters: Influence of the Physical Environment on the Spatial Distribution of Platelet Activation and Thrombin Activity During Hemostasis In Vivo "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"In Vivo Transcriptional Profiling of the Endothelium in a Novel Mouse Model of von Willebrand Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Development of Novel Anti-Fouling Molecular Probes to Detect New Platelet Ligands and Pathogenic Anti-Platelet Antibodies"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium vittatum "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Coagulation Mechanisms Beyond Hemostasis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanisms Coupling Hemostatic Factors to Tumorigenesis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"The Role of Factor XIII-A in Energy Metabolism"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Coagulation in Sickle Cell Disease"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Role of Coagulation in Liver Injury and Repair"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The Anti-Thrombotic Effect of Aspirin Is Partially Transmissible via Gut Microbe Transplantation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Hemostasis and Thrombosis: Bench to Bedside
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:20 pm
"Antithrombotic Therapy: Today and Tomorrow"
6:20 pm - 6:35 pm
Discussion
6:35 pm - 7:15 pm
"Cellular Targets in Thrombosis"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure