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Hemostasis

Gordon Research Conference

The Hemostasis and Thromboinflammation Continuum

August 4 - 9, 2024

Chair

Vice Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Hemostasis GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Program Description

The recent COVID-19 pandemic and vaccine-related thrombotic complications brought into sharp focus mechanisms by which normal hemostasis becomes dysregulated. These disorders also reveal the complexity of the hemostatic system and the significant knowledge gaps that remain in our understanding mechanisms of thromboinflammation.

The Hemostasis GRC/GRS provides a scientific forum to discuss advances in areas of blood coagulation, platelet/endothelial cell biology and fibrinolysis. First organized by hemostasis pioneers Earl W. Davie and Oscar Ratnoff in 1973, the Hemostasis GRC brings together a community of investigators interested in the biology, biochemistry, and genetics of platelets and coagulation proteins; physicians involved in the treatment of bleeding and thrombotic diseases; and scientists from small and large pharmaceutical/biotechnology companies developing new therapeutics and diagnostics for hemostatic disorders.

A key priority of the GRC/GRS is to encourage participation by women, underrepresented populations, individuals with physical disabilities, and young investigators, including graduate and postdoctoral trainees, and junior faculty.

Program Dates & Application Information

The 2024 Hemostasis GRC will be held from August 4th-9th at the Waterville Valley Conference Center, Waterville Valley, New Hampshire. The GRC is preceded by a Seminar (GRS; August 3 - 4, 2024; Waterville Valley) dedicated exclusively to trainee development and mentoring. The GRS is organized and run by trainees and requires a separate registration.

The small-format meeting of the GRC/GRS is designed to promote interactions of trainees with established investigators. As such, every attendee participates as a speaker, discussion leader, or poster presenter. All applicants are encouraged to submit an abstract for presentation at one of the scheduled poster sessions and consideration for an oral presentation at the Late-Breaking Topics session. Poster sessions are always well attended and provide a dedicated and highly-interactive forum for conversations among junior and senior investigators in the field.

Abstracts must be completed and submitted by July 6, 2024.

Related Meeting

This GRC will be held in conjunction with the "Hemostasis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Novel Structural and Biologic Insights in Hemostasis Discussion Leader:
7:40 pm - 8:05 pm	"Functional Genetics of Tissue Factor in Bleeding and Thrombotic Risk"
8:05 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"From Rigid to Ruptured: Triggering Mechanical Failure of Thrombi with tPA-Microbots"
8:45 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Von Willebrand Factor as a Regulator of Protein S Anticoagulant Activity"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Molecular and Physiologic Models of Hemostasis Discussion Leader:
9:00 am - 9:25 am	"Microfluidic Flow for Health: From Bleeding to Drug Discovery"
9:25 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Trawling for Genetic Modifiers of Hemostasis and Thrombosis Through Genome Editing in Zebrafish"
10:05 am - 10:20 am	Discussion
10:20 am - 10:45 am	Group Photo / Coffee Break
10:45 am - 11:10 am	"Next-Gen Polymeric Particles for Control of Platelet-Neutrophil/Endothelium Dynamics in Thromboinflammatory Diseases"
11:10 am - 11:25 am	Discussion
11:25 am - 11:50 am	"Production of Hemostatic Proteins During Normothermic Machine Perfusion of Human Livers for 7 Days"
11:50 am - 12:05 pm	Discussion
12:05 pm - 12:20 pm	"Bioinspired Approaches to Modulate Hemostasis"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: , and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms of Thromboinflammation Discussion Leader:
7:30 pm - 7:55 pm	"Neutrophil Inflammasome in Thromboinflammation"
7:55 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	"Biochemical and Molecular Characteristic of Anti-PF4 Antibodies and their Clinical Implications in Immune-Mediated Platelet Disorders"
8:35 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Untangling the NET: Stabilizing Neutrophil Extracellular Traps to Accelerate Bacterial Clearance and Limit Thrombosis in Sepsis"
9:15 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Protein Interactions in Hemostasis Discussion Leader:
9:00 am - 9:25 am	"Endo- and Exocytosis: Why Do They Matter For Platelet Function?"
9:25 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Coagulation Protease-Induced Endothelial Extracellular Vesicles: Their Impact on Hemostasis, Inflammation, and Hemophilia Treatment"
10:05 am - 10:20 am	Discussion
10:20 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Coagulation-Kidney Dialogue: Effects of Thrombin and DOACs on Glomerular Disease"
11:10 am - 11:25 am	Discussion
11:25 am - 11:40 am	"Crosstalk Between Coagulation and Cancer: The Role of Endothelial Von Willebrand Factor"
11:40 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Contribution of Platelet Granule Cargo Uptake and Secretion to the Initiation and Progression of Aortic Aneurysms"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Atomic-Level Structural-Omics of Platelet Membrane Proteins via Cryo-EM Followed by Build and Retrieve" (BaR) Data Processing"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Endothelial and Coagulation Cross-Talk Discussion Leader:
7:30 pm - 7:55 pm	"HS3ST and the Antithrombin-Heparan Sulfate Axis: An Important Regulator of Post-Injury Inflammation"
7:55 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	"Fate of the Fibrin(ogen) in the Injured Liver"
8:35 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Purinergic Regulation of Lung Thrombosis in Sickle Cell Disease"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Structural and Biochemical Basis of Hemostasis Discussion Leader:
9:00 am - 9:25 am	"Interactions of Multiple Covalent States of FVIII"
9:25 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Factor V Interaction with TFPI in Hemostasis, Thrombosis, and Cerebrovascular Development"
10:05 am - 10:20 am	Discussion
10:20 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Mechanistic Insights into the Autoregulation of ADAMTS13 Metalloprotease"
11:10 am - 11:25 am	Discussion
11:25 am - 11:50 am	"Targeting Fibrin Structure"
11:50 am - 12:05 pm	Discussion
12:05 pm - 12:20 pm	"Platelets in Valvular Disease"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Late Breaking Topics Discussion Leader:
7:30 pm - 7:40 pm	"Autophagy Shapes Platelet Function in Inflammatory Diseases"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"A Dual-Reporter Degradation Platform to Evaluate the Ubiquitin-Dependent Degradation of Tissue Factor"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"The Interaction of Estradiol and Platelet Biology: A Mechanistic Exploration of Sex Dimorphisms in Coagulation and Implications for Transfusion Medicine"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Ribosomal Readthrough as an Alternative Therapy for Hemophilia Patients with Nonsense Mutations"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"VWF-Platelet Interactions Drive Hepatic Injury in Experimental Acute Liver Failure"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Transducing Force into Procoagulation: PIEZO1-TMEM16F Functional Coupling in Blood Lining Cells"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Roles of ADAM17 Expression in GPIbα Maintenance During Platelet Storage and Activation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"The Glycoprotein VI Receptor - Platelet Factor 4 Axis Plays a Detrimental Role in Lung Fibrosis"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Matrix Contributions to Hemostasis Discussion Leader:
9:00 am - 9:25 am	"Human Platelet Glycoprotein IIb is Glycosylated at the Polymorphic Serine Residue That Defines Human Platelet Antigen 3b"
9:25 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Nonpolymerizable Fibrinogen in Hemostasis and Thrombosis"
10:05 am - 10:20 am	Discussion
10:20 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Thromboinflammation: A Closer View to Fibrin"
11:10 am - 11:25 am	Discussion
11:25 am - 11:50 am	"ADAMTS13 and TTP"
11:50 am - 12:05 pm	Discussion
12:05 pm - 12:25 pm	"Innovative Murine Models of Von Willebrand Disease"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Hemostatic Complications of the COVID19 Pandemic: Basic and Clinical Insights Discussion Leader:
7:30 pm - 8:15 pm	"Thromboinflammatory Mechanisms in COVID19"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	"Antithrombotic Strategies for Management of COVID19 Thrombosis"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL174102. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Hemostasis (GRS)

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